Title:The Number of Antiseizure Medications Taken and not the Lipid Profile
was Associated with Seizure Control in Adult Patients with Epilepsy
Volume: 23
Issue: 8
Author(s): Vania Aparecida Leandro-Merhi*, Glória Maria de Almeida Souza Tedrus, Giovanna Gigolotti Jacober de Moraes and Michele Novaes Ravelli
Affiliation:
- Postgraduate Program in Health Sciences, Pontifícia Universidade Católica de Campinas, São Paulo, SP, Brazil
Keywords:
Lipid metabolism, seizure control, number of antiseizure medications (ASM), epilepsy, ketogenic diet, metabolic.
Abstract: Previous studies show changes in lipid metabolism in epilepsy. The aim of this study was to
investigate the association between lipid profile and clinical variables in adult patients with epilepsy
(APE). Seventy-two APE participated in this pilot study at an outpatient neurology service. The lipid
profile (total cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoproteins
(VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides), age at disease onset,
disease duration, seizures frequency, and the number of antiseizure medications (ASM) used were
investigated. Data were analyzed using the Chi-square, Fisher, Mann-Whitney, Spearman coefficient,
and logistic regression tests. There were significant differences in HDL (p = 0.0023) and total cholesterol
(p = 0.0452) levels in connection with the number of ASM used. There was a significant difference
in seizure control among the different numbers of ASM used (p = 0.0382). Higher HDL values
were found in females (p = 0.0170). The logistic regression showed that only the number of ASM used
was associated with seizure control (p = 0.0408; OR = 2.800; 95% CI = 1.044; 7.509). The number of
ASM taken and not the lipid profile was associated with seizure control in APE.
