Title:Mini Review on Polymer-based Nano Enable System for Targeted Delivery
of Chalcone Derivatives against Cancerous Tissues: An Effective Treatment
Approach
Volume: 6
Issue: 1
Author(s): Swarupananda Mukherjee and Dipanjan Karati*
Affiliation:
- Department of Pharmaceutical Technology, School of Pharmacy, Techno India University, Kolkata, 700091, India
Keywords:
Chalcone, nano formulation, cancer, ROS, polymer, liposome, polymeric micelles, nanoparticles.
Abstract: Nanotechnology augmentation have enabled the creation of innovative colloidal preparations
that can modify the pharmacological characteristics of medications. Numerous effective applications
in the treatment of cancer have been made possible by the distinctive physicochemical and
technological characteristics of therapies based on nanomaterials. To facilitate and maximize the
interaction between cells and tissues, it is necessary to examine and modify the size, shape, charge,
and patterning of nanoscale therapeutic molecules. The flavonoids chalcones and their natural scaffolds
provide a variety of biological effects crucial for creating medicines. Plant-based anticancer
medicines represent a promising scientific and business opportunity that should be investigated. By
using traditional Chinese medicine (TCM) therapies, diseases can be avoided, and healthcare can be
enhanced. Traditional Chinese medicine is safe, straightforward, and reasonably priced. There are
numerous treatments for chronic, geriatric, and incurable diseases. Heterocyclic equivalents of chalcones
have a variety of biological properties. One of them is its anti-cancer properties, and as a result
Chalcones have drawn a huge interest in the study of malignancy. Licorice is an essential primary
ingredient in many traditional folk medicines, including Chinese and Mongolian medicine. Research
on chalcone scaffolds with strong growth-inhibitory activity in tumor cell lines was influenced
by the rising interest in this medicinal molecule, and numerous papers on these scaffolds are
now accessible. It is necessary to do a thorough examination before chalcone congeners can be developed
as a prodrug or primary chemical to treat cancer. To create a focused and efficient drug delivery
system for cancer treatment, we shall discuss chalcone derivatives and their nano-enabled
drug delivery systems in this article. It has been discussed how polymeric nanoparticles might effectively
localize in particular tumor tissues and act as drug delivery vehicles for anticancer drugs due
to their physicochemical characteristics. A promising strategy to increase the effectiveness of various
tumor treatments is the nanoencapsulation of anticancer active substances in polymeric systems.