Title:The Protective Effect of Sanggenol L Against DMBA-induced Hamster
Buccal Pouch Carcinogenesis Induces Apoptosis and Inhibits Cell
Proliferative Signalling Pathway
Volume: 27
Issue: 6
Author(s): Qing Fu, Fangming Zhang*Annamalai Vijayalakshmi
Affiliation:
- Department of Stomatology,
The Fifth People’s Hospital Of Wuxi, Wuxi, 214000, China
Keywords:
Oral cancer, sanggenol L, DMBA, apoptosis, cell proliferation, OSCC.
Abstract:
Background: Oral squamous cell carcinoma (OSCC) has a poor prognosis when treated
with surgery and chemotherapy. Therefore, a new therapy and preventative strategy for OSCC and
its underlying mechanisms are desperately needed. The purpose of this study was to examine the
chemopreventive effects of sanggenol L on oral squamous cell carcinoma (OSCC). The research
focused on molecular signalling pathways in 7,12-dimethylbenz(a)anthracene (DMBA)-induced
hamster buccal pouch (HBP) carcinogenesis.
Aim: The purpose of this study was to look at the biochemical and chemopreventive effects of
sanggenol L on 7,12-dimethylbenz(a)anthracene (DMBA)-induced HBP (hamster buccal pouch)
carcinogenesis via cell proliferation and the apoptotic pathway.
Methods: After developing squamous cell carcinoma, oral tumours continued to progress leftward
into the pouch 3 times per week for 10 weeks while being exposed to 0.5 % reactive DMBA three
times per week. Tumour growth was caused by biochemical abnormalities that induced inflammation,
increased cell proliferation, and decreased apoptosis.
Results: Oral sanggenol L (10 mg/kg bw) supplementation with cancer-induced model DMBApainted
hamsters prevented tumour occurrences, improved biochemistry, inhibited inflammatory
markers, decreased cell proliferation marker expression of tumour necrosis factor-alpha (TNF- α),
nuclear factor (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and
induced apoptosis.
Conclusion: Sanggenol L could be developed into a new medicine for the treatment of oral carcinogenesis.
