Title:Review on Hydrogel Based Systems and their use in Drug Delivery for
Wound Healing & Wound Management
Volume: 17
Issue: 4
Author(s): Meet A. Jayswal*, Priyanka Ahlawat and Ashaben Patel
Affiliation:
- Department of Pharmaceutics, Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India-391760
Keywords:
Hydrogel, topical formulation, wound healing, polymers, method of preparation of hydrogel, chemical.
Abstract: The largest organ of the human body, the skin, shields the body from the outside environment.
Despite having a great capacity for regeneration, major skin abnormalities cannot heal
on their own and must be covered with artificial skin. In recent years, significant advancements
have been achieved in the area of skin tissue engineering to create novel skin replacements. Because
of their porous as well as moisturized polymeric structural composition, hydrogels are one
of the choices with the greatest ability to imitate the natural skin microenvironment. Naturally
derived polymers, synthesized polymers, polymerizable synthetic monomolecules, as well as
mixtures of natural and synthesized polymers, can all be used to create hydrogels. They can be
used to assist in the regeneration as well as repair of the wounded dermis, epidermis or else both
by dressing various wounds permanently or temporarily. Hydrogels possess distinct properties
like lightweight, stretchable, biocompatible, and biodegradable; they have the potential to be incorporated
as flexible solutions for the care of chronic wounds. Additionally, these characteristics
make hydrogels appropriate for use in the pharmaceutical and medical industries. Physical,
chemical, and hybrid bonding are all involved in the creation of hydrogels. Several processes, including
solution casting, solution mixing, bulk crosslinking polymerization, the free radical
mechanism, radiation therapy, and the development of interpenetrating networks, are used to create
the bonding. This review primarily focuses on the type of wounds with phases in wound healing
and the many kinds of hydrogels based on cross-linking, ionic charge, physical properties,
source etc., and it also describes potential fabrication techniques for hydrogel design in biomedical
applications, drug delivery as well as wound management hydrogel systems. Hydrogel-based
systems for wound recovery and management are described, as well as current research & future
prospective of hydrogel-based drug delivery systems in wound healing for topical applications.
