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Letters in Organic Chemistry

Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Mini-Review Article

Coumarin-Derived Mannich Bases: A Review of Biological Activities

Author(s): La Quy Luong and Tran Khac Vu*

Volume 21, Issue 4, 2024

Published on: 06 October, 2023

Page: [303 - 319] Pages: 17

DOI: 10.2174/1570178620666230622113356

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Abstract

Mannich bases have a distinct place in the field of medicinal and pharmaceutical chemistry. These are used as lead compounds for the synthesis of numerous heterocyclic compounds, which possess diverse biological activities and play pivotal roles. This review covers the latest literature and knowledge on Mannich bases derived from coumarin. In addition, this review also aims to provide a comprehensive overview of recent developments in medicinal chemistry and shed light on the biological activities and structure-activity relationship (SAR) of coumarin-based Mannich bases.

Keywords: Mannich base, coumarin, biological activity, scaffold, hybrids, pharmaceutical chemistry.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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