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Current Bioactive Compounds

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ISSN (Print): 1573-4072
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Short Synthetic Peptides as COX-2 Inhibitor with Antiproliferative Activity: A Probable Future Class of Drugs

Author(s): Fazid Ali, Momitul Ahmed, Susankar Kushari, Zartaj Washmin Banu, Damiki Laloo and Jun Moni Kalita*

Volume 20, Issue 4, 2024

Published on: 01 September, 2023

Article ID: e210623218143 Pages: 8

DOI: 10.2174/1573407219666230621163500

Price: $65

Abstract

Cancer remains a leading cause of death worldwide, with traditional chemotherapy treatments causing significant side effects. Short synthetic peptides have emerged as a potential alternative due to their unique properties, including selectivity, stability and biocompatibility. Recent research has shown that short peptides can act as effective anticancer agents through their ability to inhibit the COX-2 (Cyclooxegenase-2) enzyme, a key enzyme involved in tumor growth and progression. In particular, short peptides have demonstrated promising results in targeting the tumor microenvironment, disrupting angiogenesis, and inducing apoptosis in cancer cells. This review summarizes the current literature on short peptides as anticancer agents, including their mechanisms of action and future directions for research and development. The results suggest that short peptides hold significant potential as a new class of anticancer agents and warrant further investigation.

Keywords: Short peptide, COX-2, cancer, MTT assay, cytotoxicity, synthetic peptides.

Graphical Abstract

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