Title:Understanding the Molecular Aspects of Vitamins in Parkinson’s Disease:
Present-day Concepts and Perspectives
Volume: 29
Issue: 19
Author(s): Tapan Behl*, Piyush Madaan, Aayush Sehgal, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Abdulkarim M. Meraya, Md. Khalid Anwer and Raman Verma
Affiliation:
- School of Health Science and Technology, University of Petroleum and Energy Studies, Dehradun, India
Keywords:
Parkinson’s disease, dopaminergic, levodopa, vitamins, antioxidant, neuroprotective.
Abstract: Parkinson’s disease (PD) is designated as a convoluted nerve cell devastating disorder that encompasses
the profound declination of dopaminergic (DArgic) nerve cells of the mesencephalon region. The condition
is sketched by four eminent motor manifestations, namely, slow movement, muscle tension, shaking, and
disrupted balance, but the pathology behind these manifestations is still vague. Modern-day medicinal treatment
emphasizes curbing the manifestations via introducing a gold standard (levodopa) instead of forestalling
the DArgic nerve cell destruction. Therefore, the invention and utilization of novel neuroprotective candidates
are of paramount importance in overcoming PD. Vitamins are organic molecules engaged in the modulation of
evolution, procreation, biotransformation, and other operations of the body. Numerous studies employing varying
experimental models have promulgated a prominent linkage between vitamins and PD. Vitamins, owing to
their antioxidant and gene expression modulation abilities, might be efficacious in PD therapy. Recent corroborations
depict that adequate augmentation of vitamins might de-escalate the manifestations and emergence of
PD; however, the safety of daily vitamin intake must be considered. By assembling the comprehensive information
obtained from existing publications via searching various renowned medical portals, the investigators render
in-depth insights into the physiological association amongst vitamins (D, E, B3, and C) and PD and concerned
pathological processes and their safeguarding actions in varied PD models. Furthermore, the manuscript
delineates the remedial aptitude of vitamins in PD therapy. Conclusively, augmentation of vitamins (owing to
their antioxidant and gene expression regulation capabilities) might appear as a novel and terribly efficacious
ancillary therapeutic approach for PD.
