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Mini-Review Article

A Review on Gastroprotective Mechanisms and their Augmentation by External Agents

Author(s): Poonam Sharma and Shweta Agarwal*

Volume 1, 2023

Published on: 01 August, 2023

Article ID: e220523217196 Pages: 12

DOI: 10.2174/2210299X01666230522145303

open_access

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Abstract

The oral route is the most typical way to provide medication due to its benefits, including non-invasiveness, patient compliance, and ease of medication delivery. One of the most often recommended pharmacological groups for the treatment of pain and inflammatory disease is nonsteroidal anti-inflammatory medicines. However, the major side effect of non-steroidal anti-inflammatory medicines is PUD (peptic ulcer disease). An imbalance in the action of gastroprotective and aggressive agents causes gastric ulcers. Gastroprotective mechanisms include the mucus layer, mucosal repair capacity, gastric epithelium, and gastric blood flow. The purpose of this review is to provide an update on gastroprotective mechanisms. As discussed, mucin acts as a filter, and gastric epithelial defenses include the cell barrier, stem cells, and a sensor on the mucosal surface.

Keywords: Non-steroidal anti-inflammatory medicines, Gastroprotective, Peptic ulcer disease, Luminal irritants, Mucosal injury, Mucosal surface.

[1]
Costa, M. All together now: From pacemakers to gastric peristalsis. J. Physiol., 2006, 571(1), 1.
[http://dx.doi.org/10.1113/jphysiol.2005.104372] [PMID: 16410277]
[2]
Atuma, C.; Strugala, V.; Allen, A.; Holm, L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am. J. Physiol. Gastrointest. Liver Physiol., 2001, 280(5), G922-G929.
[http://dx.doi.org/10.1152/ajpgi.2001.280.5.G922] [PMID: 11292601]
[3]
Johansson, M.E.V.; Phillipson, M.; Petersson, J.; Velcich, A.; Holm, L.; Hansson, G.C. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci., 2008, 105(39), 15064-15069.
[http://dx.doi.org/10.1073/pnas.0803124105] [PMID: 18806221]
[4]
Madushani, H.; Suzanne, H.; Joel, C.B.; Ashley, E.F.; Hill-Yardin, E.L.; Singh, T.P. The role of the gastrointestinal mucus system in intestinal homeostasis: Implications for neurological disorders. Front. Cell. Infect. Microbiol, 2020, 1, 13-25.
[5]
Sinha, M.; Gautam, L.; Shukla, P.K.; Kaur, P.; Sharma, S.; Singh, T.P. Current perspectives in NSAID-induced gastropathy. Mediators Inflamm, 2013, 2013, 258209.
[6]
DeRuiter, J. Non-steroidal antiinflammatory drugs (NSAIDS). Principles of Drug Action, 2002, 2, 1-25.
[7]
Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol., 1971, 231(25), 232-235.
[http://dx.doi.org/10.1038/newbio231232a0] [PMID: 5284360]
[8]
Saverymuttu, S.H.; Thomas, A.; Grundy, A.; Maxwell, J.D. Ileal stricturing after long-term indomethacin treatment. Postgrad. Med. J., 1986, 62(732), 967-968.
[http://dx.doi.org/10.1136/pgmj.62.732.967] [PMID: 3774733]
[9]
Wallace, J.L.; Granger, D.N. The cellular and molecular basis of gastric mucosal defense. FASEB J., 1996, 10(7), 731-740.
[http://dx.doi.org/10.1096/fasebj.10.7.8635690] [PMID: 8635690]
[10]
John, J.L. Prostaglandins, NSAIDs, and gastric mucosal protection: Why doesn’t the stomach digest itself. Physiol Rev., 1548, 88, 1548.
[11]
Giannella, R.A.; Broitman, S.A.; Zamcheck, N. Influence of gastric acidity on bacterial and parasitic enteric infections. A perspective. Ann. Intern. Med., 1973, 78(2), 271-276.
[http://dx.doi.org/10.7326/0003-4819-78-2-271] [PMID: 4567180]
[12]
Gray, J.D.; Shiner, M. Influence of gastric pH on gastric and jejunal flora. Gut, 1967, 8(6), 574-581.
[http://dx.doi.org/10.1136/gut.8.6.574] [PMID: 4865576]
[13]
Forstner, J.F. Intestinal mucins in health and disease. Digestion, 1978, 17(3), 234-263.
[http://dx.doi.org/10.1159/000198115] [PMID: 25218]
[14]
Walsh, J.H.; Peterson, W.L. The treatment of helicobacter pylori infection in the management of peptic ulcer disease. N. Engl. J. Med., 1995, 333(15), 984-991.
[http://dx.doi.org/10.1056/NEJM199510123331508] [PMID: 7666920]
[15]
Allen, A; Flemstro¨m, G. Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin. Am J Physiol Cell Physiol, 2005, 288(1), C1-19.
[http://dx.doi.org/10.1152/ajpcell.00102.2004]
[16]
Ho, S.B.; Takamura, K.; Anway, R.; Shekels, L.L.; Toribara, N.W.; Ota, H. The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig. Dis. Sci., 2004, 49(10), 1598-1606.
[http://dx.doi.org/10.1023/B:DDAS.0000043371.12671.98] [PMID: 15573912]
[17]
Bahari, H.M.; Ross, I.N.; Turnberg, L.A. Demonstration of a pH gradient across the mucus layer on the surface of human gastric mucosa in vitro. Gut, 1982, 23(6), 513-516.
[http://dx.doi.org/10.1136/gut.23.6.513] [PMID: 7076026]
[18]
Schreiber, S.; Scheid, P. Gastric mucus of the guinea pig: Proton carrier and diffusion barrier. Am. J. Physiol., 1997, 272(1 Pt 1), G63-G70.
[PMID: 9038877]
[19]
Baumgartner, H.K.; Montrose, M.H. Regulated alkali secretion acts in tandem with unstirred layers to regulate mouse gastric surface pH. Gastroenterology, 126(3), 774-783.
[http://dx.doi.org/10.1053/j.gastro.2003.11.059] [PMID: 14988832]
[20]
Björne, H.; Petersson, J.; Phillipson, M.; Weitzberg, E.; Holm, L.; Lundberg, J.O. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J. Clin. Invest., 2004, 113(1), 106-114.
[http://dx.doi.org/10.1172/JCI19019] [PMID: 14702114]
[21]
Goddard, P.J.; Kao, Y.C.J.; Lichtenberger, L.M. Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucous gel. Gastroenterology, 1990, 98(2), 361-370.
[http://dx.doi.org/10.1016/0016-5085(90)90826-M] [PMID: 2295391]
[22]
Lichtenberger, L.M. The hydrophobic barrier properties of gastrointestinal mucus. Annu. Rev. Physiol., 1995, 57(1), 565-583.
[http://dx.doi.org/10.1146/annurev.ph.57.030195.003025] [PMID: 7778878]
[23]
Wallace, J.L. Gastric resistance to acid: Is the “mucus-bicarbonate barrier” functionally redundant? Am. J. Physiol., 1989, 256(1 Pt 1), G31-G38.
[PMID: 2492159]
[24]
Sanders, M.J.; Ayalon, A.; Roll, M.; Soll, A.H. The apical surface of canine chief cell monolayers resists Hback-diffusion. Nature, •••, 3131985, 51-54.
[25]
Wright, N.A. Role of mucosal cell renewal in mucosal protection in the gastrointestinal tract. In: Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract; Allen, A.; Flemstrom, C.; Gamer, A.; Silen, W.; Turnberg, L.A., Eds.; Raven: New York, 1984; pp. 15-20.
[26]
Harding, R.K.; Morris, G.P. Cell loss from normal and stressed gastric mucosae of the rat. An ultrastructural analysis. Gastroenterology, 1977, 72(5), 857-863.
[http://dx.doi.org/10.1016/S0016-5085(77)80200-X] [PMID: 849816]
[27]
Gislason, H.; Sørbye, H.; Abdi-Dezfuli, F.; Waldum, H.L.; Svanes, K. Role of prostaglandins and histamine in hyperemic response to superficial and deep gastric mucosal injury and H+ back-diffusion in cats. Dig. Dis. Sci., 1995, 40(8), 1669-1678.
[http://dx.doi.org/10.1007/BF02212687] [PMID: 7648966]
[28]
Holzer, P.; Sametz, W. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferentneurons. Gastroenterology, 1986, 911986, 975-981.
[29]
Beck, P.L.; McKnight, W.; Lee, S.S.; Wallace, J.L. Prostaglandin modulation of the gastric vasculature and mucosal integrity in cirrhotic rats. Am. J. Physiol., 1993, 265(3 Pt 1), G453-G458.
[PMID: 8214067]
[30]
Wright, N.A.; Pike, C.; Elia, G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature, 1990, 343(6253), 82-85.
[http://dx.doi.org/10.1038/343082a0] [PMID: 2296294]
[31]
Ma, L.; Elliott, S.N.; Cirino, G.; Buret, A.; Ignarro, L.J.; Wallace, J.L. Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release. Proc. Natl. Acad. Sci., 2001, 98(11), 6470-6475.
[http://dx.doi.org/10.1073/pnas.111150798] [PMID: 11353854]
[32]
Green, FW; Kaplan, MM; Curtis, LE; Levine, PH Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor prolonged gastroduodenal mucosal hemorrhage. Astroenterology, 1978, 74, 38-43.
[33]
Green, FW Harsh Mohan textbook of Pathology, 7th edition; Health Sciences publishers: New Delhi London Philadelphia Panama, 2015.
[34]
Harrison's Principles of Internal Medicine Casper Fouzia Sir longo Jameson loscalzo; Mcgraw Hill education, 2015.
[35]
Robbins basic pathology, 9th ed.; Elsevier, 2016, pp. 564-566.
[36]
Reference davidson's principle and practice of medicine 22 MD 2014; Elsevier, 2014.
[37]
Gastritis medical physiology, 7th ed.; The Health Sciences publishers: New Delhi London, 2013.
[38]
Vaibhav, S.; Vidyasagar, G.; Shyamlila, B.B.; Nandkishor, B. Management of peptic ulcer-a review. IJIRT, 2020, 6(12)
[39]
Takeshi, K. Who needs gastroprotection in 2020. Curr Treat Options Gastro, 2020, 18, 557-573.
[40]
Lapenna, D.; De Gioia, S.; Mezzetti, A.; Grossi, L.; Festi, D.; Marzio, L.; Cuccurullo, F. H 2 -receptor antagonists are scavengers of oxygen radicals. Eur. J. Clin. Invest., 1994, 24(7), 476-481.
[http://dx.doi.org/10.1111/j.1365-2362.1994.tb02378.x] [PMID: 7957505]
[41]
Robinson, M.G.; Griffin, J.W., Jr; Bowers, J.; Kogan, F.J.; Kogut, D.G.; Lanza, F.L.; Warner, C.W. Effect of ranitidine gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs. Dig. Dis. Sci., 1989, 34(3), 424-428.
[http://dx.doi.org/10.1007/BF01536266] [PMID: 2646087]
[42]
Ehsanullah, R.S.; Page, M.C.; Tildesley, G.; Wood, J.R. Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. BMJ, 1988, 297(6655), 1017-1021.
[http://dx.doi.org/10.1136/bmj.297.6655.1017] [PMID: 3142593]
[43]
Wolfe, M.M.; Lichtenstein, D.R.; Singh, G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N. Engl. J. Med., 1999, 340(24), 1888-1899.
[http://dx.doi.org/10.1056/NEJM199906173402407] [PMID: 10369853]
[44]
Bell, N.J.; Hunt, R.H. Progress with proton pump inhibition. Yale J. Biol. Med., 1992, 65(6), 649-657.
[PMID: 1341069]
[45]
Wu, K.K. Cyclooxygenase 2 induction: Molecular mechanism and pathophysiologic roles. J. Lab. Clin. Med., 1996, 128(3), 242-245.
[http://dx.doi.org/10.1016/S0022-2143(96)90023-2] [PMID: 8783630]
[46]
Bombardier, C.; Laine, L.; Reicin, A.; Shapiro, D.; Burgos-Vargas, R.; Davis, B.; Day, R.; Ferraz, M.B.; Hawkey, C.J.; Hochberg, M.C.; Kvien, T.K.; Schnitzer, T.J. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N. Engl. J. Med., 2000, 343(21), 1520-1528.
[http://dx.doi.org/10.1056/NEJM200011233432103] [PMID: 11087881]
[47]
Saavedra, J.E.; Billiar, T.R.; Williams, D.L.; Kim, Y.M.; Watkins, S.C.; Keefer, L.K. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J. Med. Chem., 1997, 40(13), 1947-1954.
[http://dx.doi.org/10.1021/jm9701031] [PMID: 9207935]
[48]
Konturek, S.J.; Brzozowski, T.; Majka, J.; Szlachcic, A.; Pytko-Polonczyk, J. Implications of nitric oxide in the action of cytoprotective drugs on gastric mucosa. J. Clin. Gastroenterol., 1993, 17(S1), S140-S145.
[http://dx.doi.org/10.1097/00004836-199312001-00025] [PMID: 8283009]
[49]
Wallace, J.L.; Miller, M.J.S. Nitric oxide in mucosal defense: A little goes a long way. Gastroenterology, 2000, 119(2), 512-520.
[http://dx.doi.org/10.1053/gast.2000.9304] [PMID: 10930387]
[50]
Fiorucci, S.; Antonelli, E.; Mencarelli, A.; Orlandi, S.; Renga, B.; Rizzo, G.; Distrutti, E.; Shah, V.; Morelli, A. The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis. Hepatology, 2005, 42(3), 539-548.
[http://dx.doi.org/10.1002/hep.20817] [PMID: 16108046]
[51]
Lichtenberger, L.M.; Barron, M.; Marathi, U. Association of phosphatidylcholine and nsaids as a novel strategy to reduce gastrointestinal toxixity. Drugs Today, 2009, 45(12), 877-890.
[http://dx.doi.org/10.1358/dot.2009.45.12.1441075] [PMID: 20135022]
[52]
Gastroprotective Agent definition Available from: https://www.lawinsider.com/dictionary/gastroprotective agent#:~:text=Gastroprotective%20Agent%20means%20proton%20pump,injury%20to
[53]
Sascha, D.; Rod, L.W.; Michael, L.J.; Jennifer, C.N.; Noel, S.W.; Lisa, A.J. Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: A population-based case-control study. Pharmacoepidemiol Drug Saf., 2010, 19(8), 792-802.
[54]
Zidar, N.; Odar, K.; Glavac, D.; Jerse, M.; Zupanc, T.; Stajer, D. Cyclooxygenase in normal human tissues - is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? J. Cell. Mol. Med., 2009, 13(9b), 3753-3763.
[http://dx.doi.org/10.1111/j.1582-4934.2008.00430.x] [PMID: 18657230]
[55]
Gudis, K.; Sakamoto, C. The role of cyclooxygenase in gastric mucosal protection. Dig. Dis. Sci., 2005, 50(S1), S16-S23.
[http://dx.doi.org/10.1007/s10620-005-2802-7] [PMID: 16184416]
[56]
Konturek, S.J.; Konturek, P.C.; Pawlik, T.; Sliwowski, Z.; Ochmański, W.; Hahn, E.G. Duodenal mucosal protection by bicarbonate secretion and its mechanisms. J. Physiol. Pharmacol., 2004, 55(S2), 5-17.
[PMID: 15608357]
[57]
Seibert, K.; Zhang, Y.; Leahy, K.; Hauser, S.; Masferrer, J.; Perkins, W.; Lee, L.; Isakson, P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci., 1994, 91(25), 12013-12017.
[http://dx.doi.org/10.1073/pnas.91.25.12013] [PMID: 7991575]
[58]
Seibert, K.; Masferrer, J.L. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor, 1994, 4(1), 17-23.
[PMID: 8038702]
[59]
Mitchell, J.A.; Akarasereenont, P.; Thiemermann, C.; Flower, R.J.; Vane, J.R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci., 1993, 90(24), 11693-11697.
[http://dx.doi.org/10.1073/pnas.90.24.11693] [PMID: 8265610]
[60]
Miller, T. A. Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am. J. Physiol. Cell Physiol., 1983, 245(5), G601-G623.
[http://dx.doi.org/10.1152/ajpgi.1983.245.5.G601]
[61]
Somasundaram, S.; Rafi, S.; Hayllar, J.; Sigthorsson, G.; Jacob, M.; Price, A.B.; Macpherson, A.; Mahmod, T.; Scott, D.; Wrigglesworth, J.M.; Bjarnason, I. Mitochondrial damage: A possible mechanism of the “topical” phase of NSAID induced injury to the rat intestine. Gut, 1997, 41(3), 344-353.
[http://dx.doi.org/10.1136/gut.41.3.344] [PMID: 9378390]
[62]
Tomisato, W.; Tanaka, K.; Katsu, T.; Kakuta, H.; Sasaki, K.; Tsutsumi, S.; Hoshino, T.; Aburaya, M.; Li, D.; Tsuchiya, T.; Suzuki, K.; Yokomizo, K.; Mizushima, T. Membrane permeabilization by non-steroidal anti-inflammatory drugs. Biochem. Biophys. Res. Commun., 2004, 323(3), 1032-1039.
[http://dx.doi.org/10.1016/j.bbrc.2004.08.205] [PMID: 15381103]
[63]
Anticoagulants Available from: https://www.medicinenet.com/anticoagulants_drug_class_of_blood_thinners/article.htm
[64]
Zheng, H.M.; Choi, M.J.; Kim, J.M.; Cha, K.H.; Lee, K.W.; Park, Y.H.; Hong, S.S.; Lee, D.H. Centella asiatica leaf extract protects against indomethacin-induced gastric mucosal injury in rats. J. Med. Food, 2016, 19(1), 38-46.
[http://dx.doi.org/10.1089/jmf.2015.3464] [PMID: 26469560]
[65]
Gohil, K.; Patel, J.; Gajjar, A. Pharmacological review on Centella asiatica: A potential herbal cure-all. Indian J. Pharm. Sci., 2010, 72(5), 546-556.
[http://dx.doi.org/10.4103/0250-474X.78519] [PMID: 21694984]
[66]
Cestari, S.H.; Bastos, J.K.; Di Stasi, L.C. Intestinal anti-inflammatory activity of Baccharis dracunculifolia in the trinitrobenzenesulphonic acid model of rat colitis. Evid. Based Complement. Alternat. Med., 2011, 2011, 1-9.
[http://dx.doi.org/10.1093/ecam/nep081] [PMID: 19592480]
[67]
Massignani, J.J.; Lemos, M.; Maistro, E.L.; Schaphauser, H.P.; Jorge, R.F.; Sousa, J.P.B.; Bastos, J.K.; de Andrade, S.F. Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats. Phytother. Res., 2009, 23(10), 1355-1360.
[http://dx.doi.org/10.1002/ptr.2624] [PMID: 19274697]
[68]
Biondo, T.M.A.; Tanae, M.M.; Coletta, E.D.; Lima-Landman, M.T.R.; Lapa, A.J.; Souccar, C. Antisecretory actions of Baccharis trimera (Less.) DC aqueous extract and isolated compounds: Analysis of underlying mechanisms. J. Ethnopharmacol., 2011, 136(2), 368-373.
[http://dx.doi.org/10.1016/j.jep.2011.04.065] [PMID: 21575703]
[69]
Negi, P.; Gautam, S.; Sharma, A.; Rathore, C.; Sharma, L.; Upadhyay, N.; Tambuwala, M.M.; Chellappan, D.K.; Gupta, G.; Prasher, P.; Dua, K.; Agarwal, S.; Lal, U.R. Gastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence. Ther. Deliv., 2022, 13(2), 81-93.
[http://dx.doi.org/10.4155/tde-2021-0062] [PMID: 35075915]
[70]
Ruwart, M.J.; Nezamis, J.E.; Rush, B.D.; Lancaster, C.; Davis, J.P.; Nichols, N.M. Timoprazole is a unique cytoprotective agent in the rat. Digestion, 1984, 30(1), 33-40.
[71]
Lindberg, P.; Brändström, A.; Wallmark, B.; Mattsson, H.; Rikner, L.; Hoffmann, K.J. Omeprazole: The first proton pump inhibitor. Med. Res. Rev., 1990, 10(1), 1-54.
[http://dx.doi.org/10.1002/med.2610100102] [PMID: 2404184]
[72]
Stedman, C.A.M.; Barclay, M.L. Review article: Comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment. Pharmacol. Ther., 2000, 14(8), 963-978.
[http://dx.doi.org/10.1046/j.1365-2036.2000.00788.x] [PMID: 10930890]
[73]
Histamine Type-2 Receptor Antagonists (H2 Blockers). In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury;
[74]
Antacid. Available from: https://my.clevelandclinic.org/health/drugs/23076-antacid#:~:text=Antacids%20are%20a%20medicine%20that,the%2Dcounter%20without%20a%20prescription
[75]
NSAIDs: Non-steroidal anti-inflammatory drugs. Available from: https://www.spine-health.com/treatment/pain-medication/understanding-cox-2-inhibitor-side-effects
[76]
De Toledo Dias, L.F.; de Melo, E.S.; Hernandes, L.S.; Bacchi, E.M. Antiulcerogenic and antioxidant activities of Baccharis trimera (Less) DC (Asteraceae) Revista Brasileira De Farmacognosia-Brazilian. J. Pharm., 2009, 19, 309-314.
[77]
dos Reis Lívero, F.A.; da Silva, L.M.; Ferreira, D.M.; Galuppo, L.F.; Borato, D.G.; Prando, T.B.L.; Lourenço, E.L.B.; Strapasson, R.L.B.; Stefanello, M.É.A.; de Paula Werner, M.F.; Acco, A. Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid. Naunyn Schmiedebergs Arch. Pharmacol., 2016, 389(9), 985-998.
[http://dx.doi.org/10.1007/s00210-016-1262-2] [PMID: 27314669]
[78]
Petrović, S.; Dobrić, S.; Mimica-Dukić, N.; Simin, N.; Kukić, J.; Niketić, M. The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract. Phytother. Res., 2008, 22(11), 1548-1551.
[http://dx.doi.org/10.1002/ptr.2485] [PMID: 18814212]
[79]
Petrovic, S.D.; Dobric, S.; Bokonjic, D.; Niketic, M.; García-Piñeres, A.; Merfort, I. Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. J. Ethnopharmacol., 2003, 87(1), 109-113.
[http://dx.doi.org/10.1016/S0378-8741(03)00118-1] [PMID: 12787963]
[80]
Boeing, T.; da Silva, L.M.; Somensi, L.B.; Cury, B.J.; Michels Costa, A.P.; Petreanu, M.; Niero, R.; de Andrade, S.F. Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer. J. Ethnopharmacol., 2016, 184, 196-207.
[http://dx.doi.org/10.1016/j.jep.2016.02.049] [PMID: 26956376]
[81]
Frutuoso, V.; Gurjão, M.; Cordeiro, R.; Martins, M. Analgesic and anti-ulcerogenic effects of a polar extract from leaves of Vernonia condensata. Planta Med., 1994, 60(1), 21-25.
[http://dx.doi.org/10.1055/s-2006-959400] [PMID: 8134411]
[82]
de Barros, M.; Mota da Silva, L.; Boeing, T.; Somensi, L.B.; Cury, B.J.; de Moura Burci, L.; Santin, J.R.; de Andrade, S.F.; Monache, F.D.; Cechinel-Filho, V. Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and afzelin in rodents. Naunyn Schmiedebergs Arch. Pharmacol., 2016, 389(4), 403-417.
[http://dx.doi.org/10.1007/s00210-015-1208-0] [PMID: 26758066]
[83]
Bucciarelli, A.; Minetti, A.; Milczakowskyg, C.; Skliar, M. Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae). Pharm. Biol., 2010, 48(9), 1025-1030.
[http://dx.doi.org/10.3109/13880200903453131] [PMID: 20731555]
[84]
Ganjare, A.B.; Nirmal, S.A.; Rub, R.A.; Patil, A.N.; Pattan, S.R. Use of Cordia dichotoma bark in the treatment of ulcerative colitis. Pharm. Biol., 2011, 49(8), 850-855.
[http://dx.doi.org/10.3109/13880209.2010.551539] [PMID: 21696332]
[85]
Sini, K.R.; Sinha, B.N.; Rajasekaran, A. Protective effects of Capparis zeylanica Linn. Leaf extract on gastric lesions in experimental animals. Avicenna J. Med. Biotechnol., 2011, 3(1), 31-35.
[PMID: 23407576]
[86]
Debnath, S.; Biswas, D.; Ray, K.; Guha, D. Moringa oleifera induced potentiation of serotonin release by 5-HT3 receptors in experimental ulcer model. Phytomedicine, 2011, 18(2-3), 91-95.
[http://dx.doi.org/10.1016/j.phymed.2010.06.003] [PMID: 20637582]
[87]
Choudhary, M.K.; Bodakhe, S.H.; Gupta, S.K. Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats. J. Acupunct. Meridian Stud., 2013, 6(4), 214-220.
[http://dx.doi.org/10.1016/j.jams.2013.07.003] [PMID: 23972244]
[88]
Minaiyan, M.; Asghari, G.; Taheri, D.; Saeidi, M.; Nasr-Esfahani, S. Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats. Avicenna J. Phytomed., 2014, 4(2), 127-136.
[PMID: 25050310]
[89]
Mishra, V.; Agrawal, M.; Onasanwo, S.A.; Madhur, G.; Rastogi, P.; Pandey, H.P.; Palit, G.; Narender, T. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine, 2013, 20(6), 506-511.
[http://dx.doi.org/10.1016/j.phymed.2013.01.002]
[90]
Available from: https://www.researchgate.net/figure/Shows-different-gastroprotective-agents_tbl2_274654804
[91]
Antiulcer Agents. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury;
[PMID: 31643339]
[92]
Everything You Want to Know About Prostaglandins. Available from: https://www.healthline.com/health/prostaglandins#what-they-do
[93]
Prokinetic agent. Available from: https://en.wikipedia.org/wiki/Prokinetic_agent#:~:text=A%20prokinetic%20agent%20
[94]
Henry, I.J. Gastric Emptying; Reference Module in Biomedical Sciences, 2017.
[http://dx.doi.org/10.1016/B978-0-12-801238-3.64921-8]
[95]
Choung, R.S.; Talley, N.J.; Peterson, J.; Camilleri, M.; Burton, D.; Harmsen, W.S.; Zinsmeister, A.R. A double-blind, randomized, placebo-controlled trial of itopride (100 and 200 mg three times daily) on gastric motor and sensory function in healthy volunteers. Neurogastroenterol. Motil., 2007, 19(3), 180-187.
[http://dx.doi.org/10.1111/j.1365-2982.2006.00869.x] [PMID: 17300287]
[96]
Lundell, L.; Myers, J.C.; Jamieson, G.G. Is motility impaired in the entire upper gastrointestinal tract in patients with gastro-oesophageal reflux disease? Scand. J. Gastroenterol., 1996, 31(2), 131-135.
[http://dx.doi.org/10.3109/00365529609031976] [PMID: 8658034]

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