Title:Huge Primary Clear Cell Hepatocellular Carcinoma: A Case Report and
Review of Radiologic Findings
Volume: 20
Author(s): Junhyeon Jeon, Jinyoung Park*, Eunjoo Lee, Jiyeon Han, Dasom Kim, Donghyun Kim, Jungwon Park, Minha Kwag, Suyoung Yun and Hayoung Park
Affiliation:
- Department of Radiology, Inje University Busan Paik Hospital, Busan, South Korea
Keywords:
Clear cell, Carcinoma, Hepatocellular, Computed tomography, Magnetic resonance imaging, Liver.
Abstract:
Introduction:
Clear cell hepatocellular carcinoma (HCC) is a rare subtype of HCC. Histologically, clear cell HCC is characterized by the cytoplasmic
accumulation of glycogen with a clear cell appearance, constituting > 80% of tumor cells. Radiologically, clear cell HCC demonstrates early
enhancement and washout similar to conventional HCC. Occasionally, enhancing capsule and intratumoral fat are accompanied by clear cell HCC.
Case Description:
A 57-year-old male presented to our hospital with right upper quadrant abdominal pain. Ultrasonography, computed tomography, and magnetic
resonance imaging revealed a large mass with a well-defined margin in the right hemiliver. The patient underwent a right hemihepatectomy, and
the final histopathology revealed clear cell-type HCC.
Conclusion:
Distinguishing clear cell types from other types of HCC solely based on radiological findings is challenging. If hepatic tumors exhibit encapsulated
margins, enhancing rims, intratumoral fat, and arterial phase hyperenhancement/washout pattern despite their large size, consideration of clear cell
subtypes in the differential diagnosis list will aid patient management, implying better prognosis than not-otherwise-specified HCC.
