Title:Caveolae’s Behavior in Norm and Pathology
Volume: 4
Author(s): Basheer Abdullah Marzoog*
Affiliation:
- National Research Mordovia State University, Bolshevitskaya Street, 68, Saransk, Rep. Mordovia 430005, Mordovia Republic, Saransk,
Bolshevitskaya, Russia
Keywords:
Caveolin, Scaffold protein, Endothelial nitric oxide synthase, Regeneration, Pathogenesis, Caveola.
Abstract:
Objectives:
Caveolins are universal multifunctional physiologically active microparticles that collaborate in the caveolae formation to maintain the metabolic
homeostatic balance of the cells. In fact, remarkable advances in the molecular biopathology of caveolae have been made in recent years by
exploring the role of caveolae in norm and physiopathology.
Methods:
The current literature data on the caveolae behavior in norm and pathology were revised.
Results:
Caveolae are expressed in various cell types, highly concentrated in endothelial cells, cardiomyocytes, and epithelial cells. Physiologically,
caveolae contribute to maintaining a signaling balance between the various homeostatic processes, including pro-growth and pro-survival, such as
endothelial nitric oxide synthase, glycogen synthase kinase-3β, p42/p44 mitogen-activated protein kinase, PKA, SFK, PKC, Akt through regulation
of tyrosine kinases, G protein-coupled receptor, endothelial nitric oxide synthase, and MAPK pathways, and their signaling dysfunction is directly
attributed to the pathogenesis of cardiovascular diseases, regeneration inhibition, neurodegenerative diseases, infection, osteoporosis, diabetes, and
tumour induction and progression.
Conclusion:
Regulation of the ratio and penetrance of caveolae activity/expression is a clinically significant potential therapeutic strategy to enhance the current
therapies and eliminate the etiopathogenetic pathway of rising homeostatic disorders.
