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CNS & Neurological Disorders - Drug Targets

CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Nutrition, Immunity and Aging: Current Scenario and Future Perspectives in Neurodegenerative Diseases

Author(s): Camilla Barbero Mazzucca, Giuseppe Cappellano* and Annalisa Chiocchetti

Volume 23, Issue 5, 2024

Published on: 16 May, 2023

Page: [573 - 587] Pages: 15

DOI: 10.2174/1871527322666230502123255

Price: $65

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Abstract

Aging is a gradual decline of physiological function and tissue homeostasis and, in many instances, is related to increased (neuro)-degeneration, together with inflammation, becoming one of the most important risks for developing neurodegenerative diseases. Certain individual nutrients or foods in combination may counteract aging and associated neurodegenerative diseases by promoting a balance between the pro- and anti-inflammatory responses. Thus, nutrition could represent a powerful modulator of this fine balance, other than a modifiable risk factor to contrast inflammaging. This narrative review explores from a broad perspective the impact of nutrition on the hallmarks of aging and inflammation in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis Syndrome (ALS), starting from nutrients up to single foods and complex dietary patterns.

Keywords: Aging, nutrition, Alzheimer’s, Parkinson amyotrophic lateral sclerosis, inflammation, homeostasis.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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