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Current Medicinal Chemistry

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Review Article

Hydrogen Sulfide: Physiological Roles and Therapeutic Implications against COVID-19

Author(s): Sajad Abolfazli, Nima Ebrahimi, Etekhar Morabi, Mohammad Amin Asgari Yazdi, Gokhan Zengin, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*

Volume 31, Issue 21, 2024

Published on: 26 June, 2023

Page: [3132 - 3148] Pages: 17

DOI: 10.2174/0929867330666230502111227

Price: $65

TIMBC 2025
Abstract

The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) poses a major menace to economic and public health worldwide. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are two host proteins that play an essential function in the entry of SARS-- COV-2 into host cells. Hydrogen sulfide (H2S), a new gasotransmitter, has been shown to protect the lungs from potential damage through its anti-inflammatory, antioxidant, antiviral, and anti-aging effects. It is well known that H2S is crucial in controlling the inflammatory reaction and the pro-inflammatory cytokine storm. Therefore, it has been suggested that some H2S donors may help treat acute lung inflammation. Furthermore, recent research illuminates a number of mechanisms of action that may explain the antiviral properties of H2S. Some early clinical findings indicate a negative correlation between endogenous H2S concentrations and COVID-19 intensity. Therefore, reusing H2S-releasing drugs could represent a curative option for COVID-19 therapy.

Keywords: Hydrogen sulfide, cytokine storm, anti-inflammatory, anti-viral, COVID-19, coronavirus.

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