Title:A Quinquennial Review on Recent Advancements and Developments in
Search of Anti-malarial Agents
Volume: 23
Issue: 9
Author(s): Tejas M. Dhameliya*, Deepika Kathuria*, Tanvi M. Patel, Bhavarth P. Dave, Amit Z. Chaudhari and Drashtiben D. Vekariya
Affiliation:
- Department of Pharmaceutical Chemistry, L. M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, 380 009, India
- Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382 481, India
- University Centre for Research and Development, Chandigarh University, Gharuan, Punjab, 140 413, India
Keywords:
Anti-malarial agents, Malaria, Plasmodium falciparum, Heterocyclic scaffolds, Artemisinin, Resistant malaria.
Abstract: Malaria has been a major parasitic disease in tropical and subtropical regions and is estimated
to kill between one and two million people (mainly children) every year. Novel anti-malarial
agents are urgently needed to combat the malarial parasites enduring resistance to the current medications,
leading to increased morbidity and mortality. The heterocycles, holding a prominent position
in chemistry and found in both natural and synthetic sources, have shown several biological activities
including anti-malarial activity. Towards this goal, several research groups have reported the
design and development of novel and potential anti-malarial agents like artemisinin, benzimidazole,
benzothiazole, chalcone, cyclopeptide, fosmidomycin, furan, indole oxadiazole, 2-oxindoles, peroxides,
pyrazole, pyrazolines, pyridines, pyrimidine, pyrrolidine, quinazoline, quinazolinone, quinolone,
quinoline, thiazole, triazole and other scaffolds acting against newly emerging anti-malarial
targets. The present work reports the complete quinquennial coverage of anti-malarial agents reported
during 2016-2020 with a view of providing the merits and demerits of reported anti-malarial
scaffolds, structure-activity relationship, along with their in vitro/ in vivo/ in silico profiles to the
medicinal chemists working in the field of design and discovery of novel anti-malarial agents.