Current Medical Imaging

Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Case Report

Endometrial Adenofibroma in a Patient Receiving Toremifene: A Case Report

Author(s): Lu Li, Gang Liu, Li-Zhao Huang and Tao Li*

Volume 20, 2024

Published on: 26 June, 2023

Article ID: e260423216211

Pages: 4

DOI: 10.2174/1573405620666230426143620

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Abstract

Introduction: Adenofibroma is a rare benign Müllerian mixed tumor composed of epithelial and mesenchymal cells. This tumor may occasionally be associated with toremifene therapy which is used as an adjuvant drug for breast cancer.

Case Presentation: We describe a case of a 55-year-old woman with adenofibroma of the endometrium. This patient was receiving toremifene after surgery and neoadjuvant chemotherapy for breast cancer. She underwent a total abdominal hysterectomy and bilateral salpingectomy. There was no evidence of tumor residual or recurrence at 32 months of MRI follow-up.

Conclusion: In conclusion, we report a rare case of endometrial adenofibroma in a patient receiving toremifene. It must be borne in mind that long-term toremifene therapy may increase the frequency of endometrial neoplasms.

Keywords: Endometrial adenofibroma, Breast cancer, Toremifene, Magnetic resonance image, Tumor, Surgery.

[1]
Zaloudek CJ, Norris HJ. Adenofibroma and adenosarcoma of the uterus: A clinicopathologic study of 35 cases. Cancer 1981; 48(2): 354-66.
[http://dx.doi.org/10.1002/1097-0142(19810715)48:2<354::AID-CNCR2820480222>3.0.CO;2-Q] [PMID: 6263458]
[2]
Watanabe H, Harada N, Nobuhara I, Haruta N, Higashiura Y, Watanabe S. Magnetic resonance imaging and flexible hysterofiberscopic findings of a uterine adenofibroma: Case report and literature review. Case Rep Obstet Gynecol 2018; 2018: 1-8.
[http://dx.doi.org/10.1155/2018/9685683] [PMID: 29670786]
[3]
Rea D, Poole C, Gray R. Adjuvant tamoxifen: how long before we know how long? BMJ 1998; 316(7143): 1518-9.
[http://dx.doi.org/10.1136/bmj.316.7143.1518] [PMID: 9582148]
[4]
Kennedy M, Baigrie C, Manek S. Tamoxifen and the endometrium: Review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology. Int J Gynecol Pathol 1999; 18(2): 130-7.
[PMID: 10202670]
[5]
Vogel CL, Johnston MA, Capers C, Braccia D. Toremifene for breast cancer: A review of 20 years of data. Clin Breast Cancer 2014; 14(1): 1-9.
[http://dx.doi.org/10.1016/j.clbc.2013.10.014] [PMID: 24439786]
[6]
Ober WB. Uterine sarcomas: Histogenesis and taxonomy. Ann NY Acad Sci 1959; 75(2 The Uterus): 568-85.
[http://dx.doi.org/10.1111/j.1749-6632.1959.tb44576.x] [PMID: 14428153]
[7]
Pagani O, Gelber S, Price K, et al. Toremifene and tamoxifen are equally effective for early-stage breast cancer: First results of international breast cancer study group trials 12-93 and 14-93. Ann Oncol 2004; 15(12): 1749-59.
[http://dx.doi.org/10.1093/annonc/mdh463] [PMID: 15550579]
[8]
Lewis JD, Chagpar AB, Shaughnessy EA, Nurko J, McMasters K, Edwards MJ. Excellent outcomes with adjuvant toremifene or tamoxifen in early stage breast cancer. Cancer 2010; 116(10): 2307-15.
[http://dx.doi.org/10.1002/cncr.24940] [PMID: 20209619]
[9]
Zhou WB, Ding Q, Chen L, Liu XA, Wang S. Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: Results of four randomized trials. Breast Cancer Res Treat 2011; 128(3): 625-31.
[http://dx.doi.org/10.1007/s10549-011-1556-5] [PMID: 21553116]
[10]
Chung YW, Bae HS, Han SI, Song JY, Kim IS, Kang JS. Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: A case report. J Gynecol Oncol 2010; 21(4): 269-72.
[http://dx.doi.org/10.3802/jgo.2010.21.4.269] [PMID: 21278890]
[11]
Huang KT, Chen CA, Cheng WF, et al. Sonographic characteristics of adenofibroma of the endometrium following tamoxifen therapy for breast cancer: Two case reports. Ultrasound Obstet Gynecol 1996; 7(5): 363-6.
[http://dx.doi.org/10.1046/j.1469-0705.1996.07050363.x] [PMID: 8774105]
[12]
Oshima H, Miyagawa H, Sato Y, et al. Adenofibroma of the endometrium after tamoxifen therapy for breast cancer: MR findings. Abdom Imaging 2002; 27(5): 592-4.
[http://dx.doi.org/10.1007/s00261-001-0098-4] [PMID: 12173004]
[13]
Ikuta A, Tanaka Y, Mizokami T, Tsutsumi A, Sato M, Tanaka M, et al. Benign endometrial adenofibroma and polyp in patients receiving tamoxifen: Findings on transvaginal ultrasonography and magnetic resonance imaging. 2005; J Med Ultrason 32(2): 71-6.
[http://dx.doi.org/10.1007/s10396-005-0036-0] [PMID: 27277125]
[14]
Hayasaka K, Morita K, Saitoh T, Tanaka Y. Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. Comput Med Imaging Graph 2006; 30(5): 315-8.
[PMID: 16890405]
[15]
Shi H, Chen X, Lv B, Zhang X. Concurrent tamoxifen-related Müllerian adenofibromas in uterus and ovary. Int J Clin Exp Pathol 2015; 8(11): 15381-5.
[PMID: 26823898]
[16]
Lee HK, Kim SH, Cho JY, Yeon KM. Uterine adenofibroma and adenosarcoma: CT and MR findings. J Comput Assist Tomogr 1998; 22(2): 314-6.
[http://dx.doi.org/10.1097/00004728-199803000-00030] [PMID: 9530402]
[17]
Arici DS, Aker H, Yildiz E, Tasyurt A. Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. Arch Gynecol Obstet 2000; 264(2): 105-7.
[http://dx.doi.org/10.1007/s004040000080] [PMID: 11045336]
[18]
Gallardo A, Prat J. Mullerian adenosarcoma. Am J Surg Pathol 2009; 33(2): 278-88.
[http://dx.doi.org/10.1097/PAS.0b013e318181a80d] [PMID: 18941402]
[19]
Felix AS, Weissfeld JL, Stone RA, et al. Factors associated with Type I and Type II endometrial cancer. Cancer Causes Control 2010; 21(11): 1851-6.
[http://dx.doi.org/10.1007/s10552-010-9612-8] [PMID: 20628804]
[20]
Grasel RP, Outwater EK, Siegelman ES, Capuzzi D, Parker L, Hussain SM. Endometrial polyps: MR imaging features and distinction from endometrial carcinoma. Radiology 2000; 214(1): 47-52.
[http://dx.doi.org/10.1148/radiology.214.1.r00ja3647] [PMID: 10644100]