The Therapeutic Effects of Withaferin A against Cancer: Overview
and Updates

Prathapan      Abeesh; Chandrasekaran      Guruvayoorappan
doi:10.2174/1566524023666230418094708
Abstract

Cancer is a rapidly rising health problem among the global population, and this burden causes a significant challenge for public health. Current chemotherapeutic agents have different limitations, including drug resistance and severe side effects, and it demands a robust approach to accessing promising anti-cancer therapeutics. The natural compounds have been extensively studied to identify improved therapeutic agents for cancer therapy. Withaferin A (WA) is a steroidal lactone found in Withania somnifera and possesses anti-inflammatory, antioxidant, anti-angiogenesis, and anticancer properties. Multiple studies have shown that WA treatment attenuated various cancer hallmarks by inducing apoptosis and reducing angiogenesis and metastasis with reduced side effects. WA is a promising agent for the treatment of various cancer, and it targets various signaling pathways. With recent updates, the current review highlights the therapeutic implications of WA and its molecular targets in different cancer.
Keywords: Withaferin A, natural compound, signalling, cancer, targets, cancer therapy.
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DOI https://dx.doi.org/10.2174/1566524023666230418094708	Print ISSN 1566-5240
Publisher Name Bentham Science Publisher	Online ISSN 1875-5666
Current Molecular Medicine

The Therapeutic Effects of Withaferin A against Cancer: Overview and Updates

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Current Molecular Medicine

The Therapeutic Effects of Withaferin A against Cancer: Overview and Updates

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