Vitamin D Deficiency in Advanced Laryngeal Cancer and its Association
with Pharyngocutaneous Fistula Following Total Laryngectomy

Kamyar      Iravani; Yaaghoob      Khosravi; Aida      Doostkam; Amir      Soltaniesmaeili

doi:10.2174/1574886318666230331100122

Abstract

Background: Nutritional factors in developing some malignancies have been investigated recently.

Objective: In this study, we evaluated the role of vitamin D in advanced laryngeal cancer and its association with the development of pharyngocutaneous fistula (PCF) following total laryngectomy.

Study Design: A cross-sectional, case-control study was conducted.

Methods: Fifty-five patients with advanced laryngeal cancer referred for total laryngectomy were included. We also considered 55 healthy individuals after matching age and sex as a control group. Serum levels of 25(OH)D₃ were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The association of serum 25(OH)D₃ with PCF following total laryngectomy was also determined.

Results: Vitamin D was significantly lower in patients with advanced laryngeal cancer than in the control group (p < 0.001). Moreover, our results showed that a mean serum concentration of 25(OH)D₃ in patients with PCF was significantly lower than in patients without PCF (p < 0.001).

Conclusion: Vitamin D deficiency is highly prevalent in advanced laryngeal cancer, most pronounced in those who develop a PFC following total laryngectomy.

Keywords: Fistula, laryngeal neoplasms, risk factors, respiratory tract fistula, vitamin D, pharyngocutaneous fistula.

« Previous Next »

Graphical Abstract

[1]
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin  2017; 67(1): 31-50.
 [http://dx.doi.org/10.3322/caac.21386] [PMID: 27898173]

[2]
Deng Y, Wang M, Zhou L, et al. Global burden of larynx cancer, 1990-2017: Estimates from the global burden of disease 2017 study. Aging  2020; 12(3): 2545-83.
 [http://dx.doi.org/10.18632/aging.102762] [PMID: 32035421]

[3]
Dietz A, Becher H, Ramroth H. Interaction effects and population-attributable risks for smoking and alcohol on laryngeal cancer and its subsites. A case-control study from Germany. Methods Inf Med  2004; 43(5): 499-504.
 [http://dx.doi.org/10.1055/s-0038-1633906] [PMID: 15702209]

[4]
Boffetta P, Hashibe M. Alcohol and cancer. Lancet Oncol  2006; 7(2): 149-56.
 [http://dx.doi.org/10.1016/S1470-2045(06)70577-0] [PMID: 16455479]

[5]
Yang D, Shi Y, Tang Y, et al. Effect of HPV infection on the occurrence and development of laryngeal cancer: A review. J Cancer  2019; 10(19): 4455-62.
 [http://dx.doi.org/10.7150/jca.34016] [PMID: 31528209]

[6]
Parsel SM, Wu EL, Riley CA, McCoul ED. Gastroesophageal and laryngopharyngeal reflux associated with laryngeal malignancy: A systematic review and meta-analysis. Clin Gastroenterol Hepatol  2019; 17(7): 1253-64.
 [http://dx.doi.org/10.1016/j.cgh.2018.10.028]

[7]
Ferster APOC, Schubart J, Kim Y, Goldenberg D. Association between laryngeal cancer and asbestos exposure. JAMA Otolaryngol Head Neck Surg  2017; 143(4): 409-16.
 [http://dx.doi.org/10.1001/jamaoto.2016.3421] [PMID: 27918783]

[8]
Wagner M, Bolm-Audorff U, Hegewald J, et al. Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: A systematic review and meta-analysis. Occup Environ Med  2015; 72(3): 226-33.
 [http://dx.doi.org/10.1136/oemed-2014-102317] [PMID: 25398415]

[9]
Paget-Bailly S, Cyr D, Luce D. Occupational exposures and cancer of the larynx-systematic review and meta-analysis. J Occup Environ Med  2012; 54(1): 71-84.
 [http://dx.doi.org/10.1097/JOM.0b013e31823c1343] [PMID: 22157731]

[10]
Vlastarakos PV, Vassileiou A, Delicha E, Kikidis D, Protopapas D, Nikolopoulos TP. Dietary consumption patterns and laryngeal cancer risk. Ear Nose Throat J  2016; 95(6): E32-8.
 [PMID: 27304450]

[11]
Ferrer-Mayorga G, Gómez-López G, Barbáchano A, et al. Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer. Gut  2017; 66(8): 1449-62.
 [http://dx.doi.org/10.1136/gutjnl-2015-310977] [PMID: 27053631]

[12]
Akiba T, Morikawa T, Odaka M, et al. Vitamin D supplementation and survival of patients with non–small cell lung cancer: A randomized, double-blind, placebo-controlled trial. Clin Cancer Res  2018; 24(17): 4089-97.
 [http://dx.doi.org/10.1158/1078-0432.CCR-18-0483] [PMID: 30018118]

[13]
Welsh J. Vitamin D and breast cancer: Past and present. J Steroid Biochem Mol Biol  2018; 177: 15-20.
 [http://dx.doi.org/10.1016/j.jsbmb.2017.07.025] [PMID: 28746837]

[14]
Guo XF, Zhao T, Han JM, Li S, Li D. Vitamin D and liver cancer risk: A meta-analysis of prospective studies. Asia Pac J Clin Nutr  2020; 29(1): 175-82.
 [PMID: 32229457]

[15]
Altieri B, Grant WB, Della Casa S, et al. Vitamin D and pancreas: The role of sunshine vitamin in the pathogenesis of diabetes mellitus and pancreatic cancer. Crit Rev Food Sci Nutr  2017; 57(16): 3472-88.
 [http://dx.doi.org/10.1080/10408398.2015.1136922] [PMID: 27030935]

[16]
Alshahrani F, Aljohani N, Vitamin D. Deficiency, sufficiency and toxicity. Nutrients  2013; 5(9): 3605-16.
 [http://dx.doi.org/10.3390/nu5093605] [PMID: 24067388]

[17]
Bischoff-Ferrari HA. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol  2014; 810: 500-25.
 [http://dx.doi.org/10.1007/978-1-4939-0437-2_28] [PMID: 25207384]

[18]
Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G, Vitamin D. Metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev  2016; 96(1): 365-408.
 [http://dx.doi.org/10.1152/physrev.00014.2015] [PMID: 26681795]

[19]
Beckett E. More than bone health: The many roles for vitamin D. Nutrients  2020; 12(8): 2388.
 [http://dx.doi.org/10.3390/nu12082388] [PMID: 32785003]

[20]
Gil Á, Plaza-Diaz J, Mesa MD, Vitamin D. Classic and novel actions. Ann Nutr Metab  2018; 72(2): 87-95.
 [http://dx.doi.org/10.1159/000486536] [PMID: 29346788]

[21]
Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK. The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA: Cancer J Clin.   2017; 67: p. (2)93-9.

[22]
Bochen F, Balensiefer B, Körner S, et al. Vitamin D deficiency in head and neck cancer patients – prevalence, prognostic value and impact on immune function. OncoImmunology  2018; 7(9): e1476817.
 [http://dx.doi.org/10.1080/2162402X.2018.1476817] [PMID: 30228945]

[23]
Orell-Kotikangas H, Schwab U, Österlund P, Saarilahti K, Mäkitie O, Mäkitie AA. High prevalence of vitamin D insufficiency in patients with head and neck cancer at diagnosis. Head Neck  2012; 34(10): 1450-5.
 [http://dx.doi.org/10.1002/hed.21954] [PMID: 22287291]

[24]
Arem H, Weinstein SJ, Horst RL, et al. Serum 25-hydroxyvitamin D and risk of oropharynx and larynx cancers in Finnish men. Cancer Epidemiol Biomarkers Prev  2011; 20(6): 1178-84.
 [http://dx.doi.org/10.1158/1055-9965.EPI-11-0153] [PMID: 21527582]

[25]
Brtko J, Dvorak Z. Natural and synthetic retinoid X receptor ligands and their role in selected nuclear receptor action. Biochimie  2020; 179: 157-68.
 [http://dx.doi.org/10.1016/j.biochi.2020.09.027] [PMID: 33011201]

[26]
Jeon SM, Shin EA. Exploring vitamin D metabolism and function in cancer. Exp Mol Med  2018; 50(4): 1-14.
 [http://dx.doi.org/10.1038/s12276-018-0038-9] [PMID: 29657326]

[27]
Díaz L, Díaz-Muñoz M, García-Gaytán A, Méndez I. Mechanistic effects of calcitriol in cancer biology. Nutrients  2015; 7(6): 5020-50.
 [http://dx.doi.org/10.3390/nu7065020] [PMID: 26102214]

[28]
Bostick RM. Effects of supplemental vitamin D and calcium on normal colon tissue and circulating biomarkers of risk for colorectal neoplasms. J Steroid Biochem Mol Biol  2015; 148: 86-95.
 [http://dx.doi.org/10.1016/j.jsbmb.2015.01.010] [PMID: 25597952]

[29]
Bhoora S, Punchoo R. Policing cancer: Vitamin D arrests the cell cycle. Int J Mol Sci  2020; 21(23): 9296.
 [http://dx.doi.org/10.3390/ijms21239296] [PMID: 33291213]

[30]
Xiong L, Zhong L, Yu L, et al. NLS-RARα contributes to differentiation block and increased leukemogenic potential in vivo. Cell Signal  2020; 65: 109431.
 [http://dx.doi.org/10.1016/j.cellsig.2019.109431] [PMID: 31654721]

[31]
Maj E, Trynda J, Maj B, et al. Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism. J Steroid Biochem Mol Biol  2019; 193: 105431.
 [http://dx.doi.org/10.1016/j.jsbmb.2019.105431] [PMID: 31326626]

[32]
Gesmundo I, Silvagno F, Banfi D, et al. Calcitriol inhibits viability and proliferation in human malignant pleural mesothelioma cells. Front Endocrinol  2020; 11: 559586.
 [http://dx.doi.org/10.3389/fendo.2020.559586] [PMID: 33133014]

[33]
Larriba M, González-Sancho J, Barbáchano A, Niell N, Ferrer-Mayorga G, Muñoz A. Vitamin D is a multilevel repressor of wnt/b-catenin signaling in cancer cells. Cancers  2013; 5(4): 1242-60.
 [http://dx.doi.org/10.3390/cancers5041242] [PMID: 24202444]

[34]
Naseri MH, Mahdavi M, Davoodi J, Tackallou SH, Goudarzvand M, Neishabouri SH. Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer Cell Int  2015; 15(1): 55.
 [http://dx.doi.org/10.1186/s12935-015-0204-2] [PMID: 26074734]

[35]
Lansaat L, van der Noort V, Bernard SE, Eerenstein SEJ, Plaat BEC, Langeveld T, et al. Predictive factors for pharyngocutaneous fistulization after total laryngectomy: A dutch head and neck society audit. Eur Arch Otorhinolaryngol  2018; 275(3): 783-94.
 [http://dx.doi.org/10.1007/s00405-017-4861-8] [PMID: 29340771]

[36]
Wang M, Xun Y, Wang K, Lu L, Yu A, Guan B. Risk factors of pharyngocutaneous fistula after total laryngectomy: A systematic review and meta-analysis. Eur Arch Otorhinolaryngol  2020; 277(2): 585-99.
 [http://dx.doi.org/10.1007/s00405-019-05718-9] [PMID: 31712878]

[37]
Oda Y, Bikle DD. Vitamin D and calcium signaling in epidermal stem cells and their regeneration. World J Stem Cells  2020; 12(7): 604-11.
 [http://dx.doi.org/10.4252/wjsc.v12.i7.604] [PMID: 32843916]

[38]
Yuan FNF, Valiyaparambil J, Woods MC, et al. Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. Int J Oncol  2014; 44(5): 1625-33.
 [http://dx.doi.org/10.3892/ijo.2014.2338] [PMID: 24626468]

[39]
Nejatinamini S, Debenham B, Clugston R, et al. Poor vitamin status is associated with skeletal muscle loss and mucositis in head and neck cancer patients. Nutrients  2018; 10(9): 1236.
 [http://dx.doi.org/10.3390/nu10091236] [PMID: 30189611]

Rights & Permissions Print Cite

Article Metrics

27

2

Journal Information

For Authors

For Editors

For Reviewers

Explore Articles

Open Access

Open Access Articles

For Visitors

DOI https://dx.doi.org/10.2174/1574886318666230331100122	Print ISSN 1574-8863
Publisher Name Bentham Science Publisher	Online ISSN 2212-3911

Current Drug Safety

Vitamin D Deficiency in Advanced Laryngeal Cancer and its Association with Pharyngocutaneous Fistula Following Total Laryngectomy

Abstract

Graphical Abstract

Related Journals

Related Books

Related Articles