Title:Isocyanide-based Multicomponent Reactions (IMCRs) in Water or
Aqueous Biphasic Systems
Volume: 21
Issue: 2
Author(s): Chitteti Divyavani, Pannala Padmaja and Pedavenkatagari Narayana Reddy*
Affiliation:
- Department of Chemistry, School of Science, Gitam Deemed to be University, Hyderabad, Telangana, India
Keywords:
Isocyanide-based multicomponent reactions (IMCRs), water, aqueous biphasic systems, heterocyclic compounds, reaction mechanism, bond-forming reactions, organic molecules.
Abstract:
Background: Isocyanide is an intriguing one-carbon synthon that is frequently employed
in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions. Isocyanide-based
multicomponent reactions (IMCRs) are effective synthetic tools in organic synthesis for the preparation
of complex heterocyclic molecules. The IMCRs in water have become an attractive research
direction, enabling simultaneous growth of both IMCRs and green solvents towards ideal organic
synthesis.
Objective: The goal of this review is to provide a general overview of IMCRs in water or biphasic
aqueous systems for accessing various organic molecules, as well as an examination of their benefits
and mechanistic insights.
Conclusion: High atom economies, mild reaction conditions, high yields, and catalyst-free processes
are crucial features of these IMCRs in water or biphasic aqueous systems.