Title:Nano Lipid Carriers as a Promising Drug Delivery Carrier for
Neurodegenerative Disorders - An Overview of Recent Advances
Volume: 18
Issue: 1
Author(s): Vishal Kumar and Sreeja C. Nair*
Affiliation:
- Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Institute of Medical Sciences and Research,
Amrita Vishwa Vidyapeetham, Kochi, 682041, Kerala, India
Keywords:
Neurological disorder, blood-brain barrier, lipid matrix, nano lipid carrier, modified release, drug delivery.
Abstract: The last few decades have seen a rise in the number of deaths caused by neurological
disorders. The blood-brain barrier (BBB), which is very complex and has multiple
mechanisms, makes drug delivery to the brain challenging for many scientists. Lipid nanoparticles
(LNPs) such as nanoemulsions, solid-lipid nanoparticles, liposomes, and nano lipid
carriers (NLCs) exhibit enhanced bioavailability and flexibility among these nanocarriers.
NLCs are found to be very effective. In the last few decades, they have been a center
of attraction for controlled drug delivery. According to the current global status of specific
neurological disorders, out of all LNPs, NLC significantly reduces the cross-permeability
of drugs through the BBB due to their peculiar properties. They offer a host of advantages
over other carriers because of their biocompatibility, safety, non-toxicity, non-irritating behavior,
stability, high encapsulation efficiency, high drug loading, high drug targeting, control
of drug release, and ease in manufacturing. The biocompatible lipid matrix is ideally
suited as a drug carrier system due to the nano-size range. For certain neurological conditions
such as Parkinsonism, Alzheimer’s, Epilepsy, Multiple sclerosis, and Brain cancer,
we examined recent advances in NLCs to improve brain targeting of bioactive with special
attention to formulation aspects and pharmacokinetic characteristics. This article also provides
a brief overview of a critical approach for brain targeting, i.e., direct nose-to-brain
drug delivery and some recent patents published on NLC”.
