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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Oxocarbon Acids and their Derivatives in Biological and Medicinal Chemistry

Author(s): Amanda Ratto and John F. Honek*

Volume 31, Issue 10, 2024

Published on: 17 May, 2023

Page: [1172 - 1213] Pages: 42

DOI: 10.2174/0929867330666230313141452

Price: $65


The biological and medicinal chemistry of the oxocarbon acids 2,3- dihydroxycycloprop-2-en-1-one (deltic acid), 3,4-dihydroxycyclobut-3-ene-1,2-dione (squaric acid), 4,5-dihydroxy-4-cyclopentene-1,2,3-trione (croconic acid), 5,6-dihydroxycyclohex- 5-ene-1,2,3,4-tetrone (rhodizonic acid) and their derivatives is reviewed and their key chemical properties and reactions are discussed. Applications of these compounds as potential bioisosteres in biological and medicinal chemistry are examined. Reviewed areas include cell imaging, bioconjugation reactions, antiviral, antibacterial, anticancer, enzyme inhibition, and receptor pharmacology.

Keywords: Deltic acid, squaric, croconic, rhodizonic, oxocarbon acids, bioisosteres.

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