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Letters in Organic Chemistry

Letters in Organic Chemistry

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Review Article

The Biological and Pharmacological Potentials of Indole-based Heterocycles

Author(s): Shivangi Sharmaorcid of author and Shivendra Singh*

Volume 20, Issue 8, 2023

Published on: 08 March, 2023

Page: [711 - 729] Pages: 19

DOI: 10.2174/1570178620666230215121808

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Abstract

An important bioactive heterocycle having several uses in medicinal chemistry, synthetic organic chemistry, material chemistry, and natural product is indole along with its analogues. Many bioactive indole-based heterocycles have important antibacterial, anti-inflammatory, analgesic, antiviral, antimalarial, chemotherapeutic, antifungal, and anti-TB effects, as well as antioxidant capabilities. Several well-known medications, including tadalafil, rizatriptan, sumatriptan, and fluvastatin are indole- based potential bioactive compounds. Based on the existing and latest evidence, researchers have focused on developing indole-based compounds with novel biological and pharmacological properties for decades. Owing to useful bioactivities, we have described many bioactive indoles and their synthetic methods in this review article.

Keywords: Indole, pharmaceutical, heterocycles, biological activity, COX-1 & COX-2 (cyclooxygenase), agonistic effects, MCR technique.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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