Title:Retrospective Review of Chromane Analogues as Anti-protozoal Leads: A
Decade's Worth of Evolution
Volume: 23
Issue: 9
Author(s): Snehal Rajkumar Jadhav, Banoth Karan Kumar, Renuka Parshuram Joshi, Chougule Kishor Suryakant, Ala Chandu, Mohammed Muzaffar-Ur-Rehman, Yogesh Mahadu Khetmalis, Adinarayana Nandikolla, Sankaranarayan Murugesan*Kondapalli Venkata Gowri Chandra Sekhar*
Affiliation:
- Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani,
Pilani Campus, Pilani, 333031, Rajasthan, India
- Department of Chemistry, Birla Institute of Technology & Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad, Telangana, 500078, India
Keywords:
Chromone, Chromane, Leishmaniasis, Malaria, Chagas, Human African trypanosomiasis.
Abstract: Tropical, vector-borne, and neglected diseases with a limited number of medication therapies
include Leishmaniasis, Malaria, Chagas and Human African Trypanosomiasis (HAT). Chromones
are a large class of heterocyclic compounds with significant applications. This heterocycle
has long aroused the interest of scientists and the general public from biosynthetic and synthetic
points of view owing to its interesting pharmacological activities. Chromones and their hybrids and
isomeric forms proved to be an exciting scaffold to investigate these diseases. The in vitro activities
of Chromone, Chromane, and a panel of other related benzopyran class compounds against Trypanosoma
brucei rhodesiense, Trypanosoma brucei gambiense, Trypanosoma cruzi, and numerous
Leishmanial and Malarial species were investigated in our previous studies. The current article
briefly describes the neglected diseases and the current treatment. This review aims to attempt to
find better alternatives by scrutinizing natural and synthetic derivatives for which chromones and
their analogues were discovered to be a new and highly effective scaffold for the treatment of neglected
diseases, including compounds with dual activity or activity against multiple parasites. Additionally,
the efficacy of other new scaffolds was also thoroughly examined. This article also discusses
prospects for identifying more unique targets for the disease, focusing on flavonoids as drug
molecules that are less cytotoxic and high antiprotozoal potential. It also emphasizes the changes
that can be made while searching for potential therapies-comparing existing treatments against protozoal
diseases and the advantages of the newer chromone analogues over them. Finally, the structure-
activity relationship at each atom of the chromone has also been highlighted.
