Title:Natural Compounds for Carcinoma Therapy by Wingless Signaling Pathway
Down-regulation
Volume: 19
Issue: 6
Author(s): Smriti Ojha, Rahul Kumar Mishra, Sudhanshu Mishra*, Amrita Singh and Shweta Kumari
Affiliation:
- Department of Pharmaceutical Science and Technology, Madan Mohan Malviya University of Technology, Gorakhpur,
India
Keywords:
WNT, discovery process, cancers, GSK-3 protein, herbal compounds, TNBC, receptors.
Abstract: Cancer is a prominent cause of death that places a significant financial strain on the
healthcare system. Because of its prevalence, there is unquestionably unmet need for new chemotherapeutics.
Atypical activation and deregulation of the wingless (Wnt) signaling pathway are
considered one of the major causes of various types of carcinomas. This receptor activation is directly
correlated with the activation of β -catenin and β -catenin-dependent transcription. In the
modern era of drug development, natural compounds have shown to be an unrivaled source of
anticancer medications. Herbal compounds have been identified as potent β-catenin signaling inhibitors,
mainly by their downregulation, modulating its phosphorylation, increasing ubiquitination
and proteasomal destruction, blocking nuclear translocation, or other molecular mechanisms.
In vitro and in vivo studies have revealed that these natural product inhibitors can prevent and
treat cancer in a variety of cancer models. Natural products have the potential to be promising
novel molecules for cancer treatment, making them an essential topic of study. The importance of
natural products in blocking the numerous signaling pathways that promote carcinogenesis is explored
in this review, paving the way for developing and discovering anticancer medicines.
