Title:LncRNA: An Important Regulator of Atherosclerosis
Volume: 30
Issue: 38
Author(s): Yun Ma*, Siqi He, Qiao Xie, Zhihan Tang and Zhisheng Jiang*
Affiliation:
- Department of Biochemistry & Molecular Biology, Hengyang Medical School, University of South China,
Hengyang, 421001, China
- Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of
Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic
Disease, Hengyang Medical School, University of South China, Hengyang, 421001, China
- Hunan
Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School,
University of South China, Hengyang, 421001, China
- Department of Biochemistry & Molecular Biology, Hengyang Medical School, University of South China,
Hengyang, 421001, China;
- Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of
Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic
Disease, Hengyang Medical School, University of South China, Hengyang, 421001, China
Keywords:
lncRNAs, atherosclerosis, ceRNA, biomarker, prognosis, drug discovery.
Abstract: Long non-coding RNA (lncRNA) is a kind of biomolecule that can regulate
important life activities such as cell proliferation, apoptosis, differentiation, aging, and
body development. It has been found that lncRNAs are closely related to various diseases.
In cardiovascular diseases, lncRNAs affect the expression level of related genes in
atherosclerotic plaques, which are closely related to endothelial dysfunction, smooth muscle
cell proliferation, macrophage dysfunction, abnormal lipid metabolism, and cellular
autophagy, thus participating in regulating the occurrence and development of AS. In
view of this, investigating the role of lncRNAs in regulating cardiac gene networks on
cardiovascular system diseases has attracted much clinical attention and may be a novel
target for AS therapy. This paper focuses on lncRNAs related to AS, explores the relationship
between lncRNAs and AS, suggests the role of lncRNAs in the prevention and
treatment of AS, and expects the application of more lncRNAs as the marker in the clinical
diagnosis and treatment of AS.
