Title:Exploring the Role of Nanotherapeutics for Diagnosis and Treatment of
Solid Tumor
Volume: 20
Issue: 1
Author(s): Ravinder Verma, Rokeya Akter, Manish Kumar, Shailendra Bhatt, Abhishek Tiwari, Varsha Tiwari, Priti Tagde, Parijat Pandey, Vineet Mittal, Deepika Purohit, Rakesh Redhu, Md. Habibur Rahman and Deepak Kaushik*
Affiliation:
- Department of Pharmaceutical Sciences, Maharshi
Dayanand University, Rohtak - 124001, India
Keywords:
Nanotechnology, solid tumors, nanotheranostics, multidrug resistance, detection, therapy, cancer.
Abstract:
Background: Tumors are increasingly heterogeneous throughout the process of their
growth, producing a mixed-cell community with a range of molecular features and susceptibility
to therapies. Nanotechnology has shown tremendous potential in diagnosing and treating solid
tumors.
Objective: Most cancer-related deaths are attributed to the lack of early detection and effective
treatment. Its early diagnosis helps overall survival and health-related quality of life in patients
identified with cancer. Nanosystems are favorable for endocytic intracellular retention, high drug
loading, enhanced therapeutic efficacy, greater drug-circulation time, superior dose scheduling
for patient compliance, and site-specific targeting. Integrating nanosystems into biomedical applications
will also reintroduce medicines that are no longer used in clinical practice because of
certain drawbacks and help the identification of new active medicines with their sub-optimal
kinetic profiles. This review provides insights about the targeted cancer treatment based on active
targeting (folate receptor-α, heat shock protein, receptor 2 for epidermal human growth
factor, and CD44 receptor) and various nano device-based systems.
Methodology: The highly relevant articles were retrieved using various search engines, including
Web of Sciences, Science Direct, Scihub, PubMed, Scopus, PubChem, Google Scholar, and
others. The keywords and phrases used for the search are “liposomes,” “quantum dots,” “nanoparticles,”
“nanocrystals,” “photodynamic therapy,” “passive targeting,” “active targeting,” “nanomaterials,”
“nanotechnology,” “cancer,” “nanotheranostics” and several others. In this review,
we briefly introduced the concept of the contribution of nanotheranostics to cancer therapy with
their recent findings. We also discuss the role of biosensor-based nanosystems in cancer.
Conclusion: This review addresses nanotechnology’s exciting role in identifying, imaging, and
managing solid tumors and their immense potential.
