Title:Metabolic Reprogramming of Microglia in Sepsis-Associated Encephalopathy:
Insights from Neuroinflammation
Volume: 21
Issue: 9
Author(s): Shenjia Gao, Yi Jiang, Zhaoyuan Chen, Xiaoqiang Zhao, Jiahui Gu, Han Wu, Yun Liao, Hao Sun, Jun Wang*Wankun Chen*
Affiliation:
- Department of
Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, School of
Basic Medical Science, Fudan University, 200032 Shanghai, China
- Department of Anesthesiology, Cancer Center, Zhongshan Hospital, Fudan University, 180# Feng-Lin Road, Shanghai,
200032, China
- Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China
- Fudan Zhangjiang Institute, Shanghai, 201203, China
Keywords:
Sepsis-associated encephalopathy, neuroinflammation, microglia, metabolic reprogramming, sepsis, microglia.
Abstract: Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by sepsis that
manifests as a range of brain dysfunctions from delirium to coma. It is a relatively common complication
of sepsis associated with poor patient prognosis and mortality. The pathogenesis of SAE involves
neuroinflammatory responses, neurotransmitter dysfunction, blood-brain barrier (BBB) disruption, abnormal
blood flow regulation, etc. Neuroinflammation caused by hyperactivation of microglia is considered
to be a key factor in disease development, which can cause a series of chain reactions, including
BBB disruption and oxidative stress. Metabolic reprogramming has been found to play a central
role in microglial activation and executive functions. In this review, we describe the pivotal role of energy
metabolism in microglial activation and functional execution and demonstrate that the regulation
of microglial metabolic reprogramming might be crucial in the development of clinical therapeutics
for neuroinflammatory diseases like SAE.
