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Current Cardiology Reviews

Editor-in-Chief

ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

First Trimester Tricuspid Regurgitation: Clinical Significance

Author(s): Sofia Teixeira* and Luís. Guedes-Martins

Volume 19, Issue 3, 2023

Published on: 06 January, 2023

Article ID: e061222211643 Pages: 12

DOI: 10.2174/1573403X19666221206115642

Price: $65

Abstract

Tricuspid regurgitation is a cardiac valvular anomaly that consists of the return of blood to the right atrium during systole due to incomplete valve closure. This structure can be visualized on ultrasound between 11 and 14 weeks of gestation in most cases. Despite being a common finding, even in healthy fetuses, the presence of tricuspid regurgitation may be associated with chromosomal and structural abnormalities. The evaluation of tricuspid flow and the presence of regurgitation on first-trimester ultrasound has shown promising results regarding its role in the early detection of aneuploidies, congenital heart defects, and other adverse perinatal outcomes. This review article aims to demonstrate the importance of tricuspid regurgitation as a secondary marker, and consequently, significant benefits of its early detection when added to the combined first-trimester screening. Its value will be discussed, namely its sensitivity and specificity, alone and together with other current markers in the fetal assessment performed in the first-trimester ultrasound.

Keywords: Doppler, fetal echocardiography, tricuspid valve, tricuspid regurgitation, chromosomal abnormality, congenital heart defect.

Graphical Abstract
[1]
Falcon O, Faiola S, Huggon I, Allan L, Nicolaides KH. Fetal tricuspid regurgitation at the 11 + 0 to 13 + 6-week scan: Association with chromosomal defects and reproducibility of the method. Ultrasound Obstet Gynecol 2006; 27(6): 609-12.
[http://dx.doi.org/10.1002/uog.2736] [PMID: 16526003]
[2]
Ozkaya O, Sezik M, Ozbasar D, Kaya H. Abnormal ductus venosus flow and tricuspid regurgitation at 11-14 weeks’ gestation have high positive predictive values for increased risk in first-trimester combined screening test: Results of a pilot study. Taiwan J Obstet Gynecol 2010; 49(2): 145-50.
[http://dx.doi.org/10.1016/S1028-4559(10)60031-9] [PMID: 20708518]
[3]
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH. Diagnosis of major heart defects by routine first-trimester ultrasound examination: Association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus. Ultrasound Obstet Gynecol 2020; 55(5): 637-44.
[http://dx.doi.org/10.1002/uog.21956] [PMID: 31875326]
[4]
Kagan KO, Valencia C, Livanos P, Wright D, Nicolaides KH. Tricuspid regurgitation in screening for trisomies 21, 18 and 13 and Turner syndrome at 11 + 0 to 13 + 6 weeks of gestation. Ultrasound Obstet Gynecol 2009; 33(1): 18-22.
[http://dx.doi.org/10.1002/uog.6264] [PMID: 19031473]
[5]
Wiechec M, Nocun A, Wiercinska E, Beithon J, Knafel A. First trimester tricuspid regurgitation and fetal abnormalities. J Perinat Med 2015; 43(5): 597-603.
[http://dx.doi.org/10.1515/jpm-2014-0058] [PMID: 24799402]
[6]
Park JE, Jo HC, Lee SM, Baek JC, Cho IA, Lee SA. Mild fetal tricuspid regurgitation in the first trimester as a predictor of perinatal outcomes. Medicina 2021; 57(6): 637.
[http://dx.doi.org/10.3390/medicina57060637] [PMID: 34205479]
[7]
Khalil A, Nicolaides KH. Fetal heart defects: Potential and pitfalls of first-trimester detection. Semin Fetal Neonatal Med 2013; 18(5): 251-60.
[http://dx.doi.org/10.1016/j.siny.2013.05.004] [PMID: 23751926]
[8]
Clerici G, Romanelli M, Tosto V, Tsibizova V, Di Renzo GC. Fetal transient tricuspid valve regurgitation: Sonographic features and clinical evolution. J Matern Fetal Neonatal Med 2021; 34(15): 2435-9.
[http://dx.doi.org/10.1080/14767058.2019.1667326] [PMID: 31550963]
[9]
Salazar Trujillo A, Rincón-Guio C, López Narváez L, Cáceres J, Charry JD. First trimester sonographic diagnosis of orofacial defects. Review of literature. J Matern Fetal Neonatal Med 2020; 33(18): 3200-6.
[http://dx.doi.org/10.1080/14767058.2019.1570114] [PMID: 30688130]
[10]
Rao R, Platt LD. Ultrasound screening: Status of markers and efficacy of screening for structural abnormalities. Semin Perinatol 2016; 40(1): 67-78.
[http://dx.doi.org/10.1053/j.semperi.2015.11.009] [PMID: 26777687]
[11]
Volpe P, Ubaldo P, Volpe N, et al. Fetal cardiac evaluation at 11-14 weeks by experienced obstetricians in a low-risk population. Prenat Diagn 2011; 31(11): 1054-61.
[http://dx.doi.org/10.1002/pd.2831] [PMID: 21800333]
[12]
Carvalho JS, Allan LD, Chaoui R, et al. ISUOG Practice Guidelines (updated): Sonographic screening examination of the fetal heart. Ultrasound Obstet Gynecol 2013; 41(3): 348-59.
[http://dx.doi.org/10.1002/uog.12403] [PMID: 23460196]
[13]
Stümpflen I, Stümpflen A, Wimmer M, Bernaschek G. Effect of detailed fetal echocardiography as part of routine prenatal ultrasonographic screening on detection of congenital heart disease. Lancet 1996; 348(9031): 854-7.
[http://dx.doi.org/10.1016/S0140-6736(96)04069-X] [PMID: 8826811]
[14]
Karadzov ON, Egic A, Damnjanovic-Pazin B, Lukic R, Joksic I, Mikovic Z. Screening performance of congenital heart defects in first trimester using simple cardiac scan, nuchal translucency, abnormal ductus venosus blood flow and tricuspid regurgitation. Congenit Heart Dis 2019; 14(6): 1094-101.
[http://dx.doi.org/10.1111/chd.12852] [PMID: 31573148]
[15]
Carvalho JS. Fetal heart scanning in the first trimester. Prenat Diagn 2004; 24(13): 1060-7.
[http://dx.doi.org/10.1002/pd.1063] [PMID: 15614834]
[16]
Faiola S, Tsoi E, Huggon IC, Allan LD, Nicolaides KH. Likelihood ratio for trisomy 21 in fetuses with tricuspid regurgitation at the 11 to 13 + 6-week scan. Ultrasound Obstet Gynecol 2005; 26(1): 22-7.
[http://dx.doi.org/10.1002/uog.1922] [PMID: 15937972]
[17]
Pang CC, Pan W, Zhang ZW, et al. Prenatal interventional therapy in two cases with critical pulmonary stenosis or pulmonary atresia with intact ventricular septum. Zhonghua Er Ke Za Zhi 2018; 56(6): 445-50.
[PMID: 29886608]
[18]
Buijtendijk MFJ, Barnett P, Hoff MJB. Development of the human heart. Am J Med Genet C Semin Med Genet 2020; 184(1): 7-22.
[http://dx.doi.org/10.1002/ajmg.c.31778] [PMID: 32048790]
[19]
Tan CMJ, Lewandowski AJ. The transitional heart: From early embryonic and fetal development to neonatal life. Fetal Diagn Ther 2020; 47(5): 373-86.
[http://dx.doi.org/10.1159/000501906] [PMID: 31533099]
[20]
Oliver R, Basit H. Embryology, Fertilization. Treasure Island, FL: StatPearls 2021.
[21]
Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE. Basics of cardiac development for the understanding of congenital heart malformations. Pediatr Res 2005; 57(2): 169-76.
[http://dx.doi.org/10.1203/01.PDR.0000148710.69159.61] [PMID: 15611355]
[22]
Armstrong EJ, Bischoff J. Heart valve development: Endothelial cell signaling and differentiation. Circ Res 2004; 95(5): 459-70.
[http://dx.doi.org/10.1161/01.RES.0000141146.95728.da] [PMID: 15345668]
[23]
Buckingham M, Meilhac S, Zaffran S. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 2005; 6(11): 826-35.
[http://dx.doi.org/10.1038/nrg1710] [PMID: 16304598]
[24]
Moorman A, Webb S, Brown NA, Lamers W, Anderson RH. Development of the heart: (1) Formation of the cardiac chambers and arterial trunks. Br Heart J 2003; 89(7): 806-14.
[http://dx.doi.org/10.1136/heart.89.7.806] [PMID: 12807866]
[25]
Sadler TW. Langman’s medical embryology. Baltimore, Md.: Lippincott Williams & Wilkins 2003.
[26]
O’Donnell A, Yutzey KE. Mechanisms of heart valve development and disease. Development 2020; 147(13): dev183020.
[http://dx.doi.org/10.1242/dev.183020] [PMID: 32620577]
[27]
Hinton RB, Yutzey KE. Heart valve structure and function in development and disease. Annu Rev Physiol 2011; 73(1): 29-46.
[http://dx.doi.org/10.1146/annurev-physiol-012110-142145] [PMID: 20809794]
[28]
Collins-Nakai R, McLaughlin P. How congenital heart disease originates in fetal life. Cardiol Clin 2002; 20(3): 367-83.
[http://dx.doi.org/10.1016/S0733-8651(02)00008-5] [PMID: 12371006]
[29]
Ayoub S, Ferrari G, Gorman RC, Gorman JH, Schoen FJ, Sacks MS. Heart valve biomechanics and underlying mechanobiology. Compr Physiol 2016; 6(4): 1743-80.
[http://dx.doi.org/10.1002/cphy.c150048] [PMID: 27783858]
[30]
Person AD, Klewer SE, Runyan RB. Cell biology of cardiac cushion development. Int Rev Cytol 2005; 243: 287-335.
[http://dx.doi.org/10.1016/S0074-7696(05)43005-3] [PMID: 15797462]
[31]
de Lange FJ, Moorman AFM, Anderson RH, et al. Lineage and morphogenetic analysis of the cardiac valves. Circ Res 2004; 95(6): 645-54.
[http://dx.doi.org/10.1161/01.RES.0000141429.13560.cb] [PMID: 15297379]
[32]
Combs MD, Yutzey KE. Heart valve development: Regulatory networks in development and disease. Circ Res 2009; 105(5): 408-21.
[http://dx.doi.org/10.1161/CIRCRESAHA.109.201566] [PMID: 19713546]
[33]
MacGrogan D, Luxán G, Driessen-Mol A, Bouten C, Baaijens F, de la Pompa JL. How to make a heart valve: From embryonic development to bioengineering of living valve substitutes. Cold Spring Harb Perspect Med 2014; 4(11): a013912.
[http://dx.doi.org/10.1101/cshperspect.a013912] [PMID: 25368013]
[34]
Misfeld M, Sievers HH. Heart valve macro- and microstructure. Philos Trans R Soc Lond B Biol Sci 2007; 362(1484): 1421-36.
[http://dx.doi.org/10.1098/rstb.2007.2125] [PMID: 17581807]
[35]
Merryman WD, Youn I, Lukoff HD, et al. Correlation between heart valve interstitial cell stiffness and transvalvular pressure: Implications for collagen biosynthesis. Am J Physiol Heart Circ Physiol 2006; 290(1): H224-31.
[http://dx.doi.org/10.1152/ajpheart.00521.2005] [PMID: 16126816]
[36]
Aktas EO, Govsa F, Kocak A, Boydak B, Yavuz IC. Variations in the papillary muscles of normal tricuspid valve and their clinical relevance in medicolegal autopsies. Saudi Med J 2004; 25(9): 1176-85.
[PMID: 15448762]
[37]
The Fetal Medicine Foundation. Tricuspid regurgitation: Newest ultrasound marker to be included in first trimester risk calculation. Fetal Med Found 11–13+6 Weeks Scan Project U S Newslett 2006; 2: 2.
[38]
McGee DC. Evaluation of first-trimester tricuspid regurgitation for Down syndrome screening. J Perinat Neonatal Nurs 2008; 22(4): 282-90.
[http://dx.doi.org/10.1097/01.JPN.0000341358.53069.4a] [PMID: 19011492]
[39]
Falcon O, Auer M, Gerovassili A, Spencer K, Nicolaides KH. Screening for trisomy 21 by fetal tricuspid regurgitation, nuchal translucency and maternal serum free β-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks. Ultrasound Obstet Gynecol 2006; 27(2): 151-5.
[http://dx.doi.org/10.1002/uog.2699] [PMID: 16388509]
[40]
The Fetal Medicine Foundation. Tricuspid flow Available from: https://fetalmedicine.org/fmf-certification-2/tricuspid-flow
[41]
Scala C, Morlando M, Familiari A, et al. Fetal tricuspid regurgitation in the first trimester as a screening marker for congenital heart defects: systematic review and meta-analysis. Fetal Diagn Ther 2017; 42(1): 1-8.
[http://dx.doi.org/10.1159/000455947] [PMID: 28482343]
[42]
Borrell A. Promises and pitfalls of first trimester sonographic markers in the detection of fetal aneuploidy. Prenat Diagn 2009; 29(1): 62-8.
[http://dx.doi.org/10.1002/pd.2182] [PMID: 19097037]
[43]
Witters G, Van Robays J, Willekes C, et al. Trisomy 13, 18, 21, triploidy and turner syndrome: The 5T’s. Look at the hands. Facts Views Vis ObGyn 2011; 3(1): 15-21.
[PMID: 24753843]
[44]
Chen CP. Prenatal sonographic features of fetuses in trisomy 13 pregnancies (III). Taiwan J Obstet Gynecol 2009; 48(4): 342-9.
[http://dx.doi.org/10.1016/S1028-4559(09)60322-3] [PMID: 20045754]
[45]
Nicolaides KH. First-trimester screening for chromosomal abnormalities. Semin Perinatol 2005; 29(4): 190-4.
[http://dx.doi.org/10.1053/j.semperi.2005.06.001] [PMID: 16104667]
[46]
Rajs B. Nocuń A, Matyszkiewicz A, et al. First-trimester presentation of ultrasound findings in trisomy 13 and validation of multiparameter ultrasound-based risk calculation models to detect trisomy 13 in the late first trimester. J Perinat Med 2021; 49(3): 341-52.
[http://dx.doi.org/10.1515/jpm-2020-0383] [PMID: 33068386]
[47]
Rosa RF, Rosa RC, Zen PR, Graziadio C, Paskulin GA. Trisomy 18: Review of the clinical, etiologic, prognostic, and ethical aspects. Rev Paul Pediatr 2013; 31(1): 111-20.
[http://dx.doi.org/10.1590/S0103-05822013000100018] [PMID: 23703053]
[48]
Traisrisilp K, Sirichotiyakul S, Tongprasert F, et al. First trimester genetic sonogram for screening fetal Down syndrome: A population-based study. Taiwan J Obstet Gynecol 2021; 60(4): 706-10.
[http://dx.doi.org/10.1016/j.tjog.2021.05.021] [PMID: 34247811]
[49]
Karadzov-Orlic N, Egic A, Milovanovic Z, et al. Improved diagnostic accuracy by using secondary ultrasound markers in the first-trimester screening for trisomies 21, 18 and 13 and Turner syndrome. Prenat Diagn 2012; 32(7): 638-43.
[http://dx.doi.org/10.1002/pd.3873] [PMID: 22570267]
[50]
Sainz JA, Serrano R, Borrero C, Turmo E. First trimester contingent test as a screening method for Down’s syndrome. A prospective study in the general population. J Matern Fetal Neonatal Med 2012; 25(11): 2221-4.
[http://dx.doi.org/10.3109/14767058.2012.684168] [PMID: 22524587]
[51]
Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O. Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: Results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening. Ultrasound Obstet Gynecol 2005; 25(3): 221-6.
[http://dx.doi.org/10.1002/uog.1860] [PMID: 15736186]
[52]
Bindra R, Heath V, Liao A, Spencer K, Nicolaides KH. One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: A prospective study of 15 030 pregnancies. Ultrasound Obstet Gynecol 2002; 20(3): 219-25.
[http://dx.doi.org/10.1046/j.1469-0705.2002.00808.x] [PMID: 12230441]
[53]
Mula R, Grande M, Bennasar M, et al. Further insights into diastolic dysfunction in first-trimester trisomy-21 fetuses. Ultrasound Obstet Gynecol 2015; 45(2): 205-10.
[http://dx.doi.org/10.1002/uog.13380] [PMID: 24706444]
[54]
Ghaffari SR, Tahmasebpour AR, Jamal A, et al. First-trimester screening for chromosomal abnormalities by integrated application of nuchal translucency, nasal bone, tricuspid regurgitation and ductus venosus flow combined with maternal serum free β-hCG and PAPP-A: A 5-year prospective study. Ultrasound Obstet Gynecol 2012; 39(5): 528-34.
[http://dx.doi.org/10.1002/uog.10051] [PMID: 21793085]
[55]
Flood K, Malone FD. Screening for fetal abnormalities with ultrasound. Curr Opin Obstet Gynecol 2008; 20(2): 139-45.
[http://dx.doi.org/10.1097/GCO.0b013e3282f73253] [PMID: 18388813]
[56]
van der Linde D, Konings EEM, Slager MA, et al. Birth prevalence of congenital heart disease worldwide: A systematic review and meta-analysis. J Am Coll Cardiol 2011; 58(21): 2241-7.
[http://dx.doi.org/10.1016/j.jacc.2011.08.025] [PMID: 22078432]
[57]
Clur SAB, Bilardo CM. Early detection of fetal cardiac abnormalities: How effective is it and how should we manage these patients? Prenat Diagn 2014; 34(13): 1235-45.
[http://dx.doi.org/10.1002/pd.4466] [PMID: 25052917]
[58]
van Velzen CL, Clur SA, Rijlaarsdam MEB, et al. Prenatal detection of congenital heart disease-results of a national screening programme. BJOG 2016; 123(3): 400-7.
[http://dx.doi.org/10.1111/1471-0528.13274] [PMID: 25625301]
[59]
Turan S, Asoglu MR, Ozdemir H, Seger L, Turan OM. Accuracy of the standardized early fetal heart assessment in excluding major congenital heart defects in high-risk population: A single-center experience. J Ultrasound Med 2021; 41(4): 961-9.
[PMID: 34288033]
[60]
Souka AP, Pilalis A, Kavalakis Y, Kosmas Y, Antsaklis P, Antsaklis A. Assessment of fetal anatomy at the 11-14-week ultrasound examination. Ultrasound Obstet Gynecol 2004; 24(7): 730-4.
[http://dx.doi.org/10.1002/uog.1775] [PMID: 15586371]
[61]
Allan LD. Echocardiographic detection of congenital heart disease in the fetus: Present and future. Heart 1995; 74(2): 103-6.
[http://dx.doi.org/10.1136/hrt.74.2.103] [PMID: 7546984]
[62]
Oşvar FN, Raţiu AC, Voiţă-Mekereş F, et al. Cardiac axis evaluation as a screening method for detecting cardiac abnormalities in the first trimester of pregnancy. Rom J Morphol Embryol 2020; 61(1): 137-42.
[http://dx.doi.org/10.47162/RJME.61.1.15] [PMID: 32747904]
[63]
Salvesen KÅ, Lees C, Abramowicz J, Brezinka C, ter Haar G, Maršál K. Safe use of doppler ultrasound during the 11 to 13 + 6-week scan: Is it possible? Ultrasound Obstet Gynecol 2011; 37(6): 625-8.
[http://dx.doi.org/10.1002/uog.9025] [PMID: 21618312]
[64]
Sinkovskaya ES, Chaoui R, Karl K, Andreeva E, Zhuchenko L, Abuhamad AZ. Fetal cardiac axis and congenital heart defects in early gestation. Obstet Gynecol 2015; 125(2): 453-60.
[http://dx.doi.org/10.1097/AOG.0000000000000608] [PMID: 25568997]
[65]
Huggon IC, DeFigueiredo DB, Allan LD. Tricuspid regurgitation in the diagnosis of chromosomal anomalies in the fetus at 11-14 weeks of gestation. Br Heart J 2003; 89(9): 1071-3.
[http://dx.doi.org/10.1136/heart.89.9.1071] [PMID: 12923032]
[66]
Persico N, Moratalla J, Lombardi CM, Zidere V, Allan L, Nicolaides KH. Fetal echocardiography at 11-13 weeks by transabdominal high-frequency ultrasound. Ultrasound Obstet Gynecol 2011; 37(3): 296-301.
[http://dx.doi.org/10.1002/uog.8934] [PMID: 21229572]
[67]
Pereira S, Ganapathy R, Syngelaki A, Maiz N, Nicolaides KH. Contribution of fetal tricuspid regurgitation in first-trimester screening for major cardiac defects. Obstet Gynecol 2011; 117(6): 1384-91.
[http://dx.doi.org/10.1097/AOG.0b013e31821aa720] [PMID: 21606749]
[68]
Sairam S, Carvalho JS. Early fetal echocardiography and anomaly scan in fetuses with increased nuchal translucency. Early Hum Dev 2012; 88(5): 269-72.
[http://dx.doi.org/10.1016/j.earlhumdev.2012.02.008] [PMID: 22464566]
[69]
Reller MD, Rice MJ, McDonald RW. Tricuspid regurgitation in newborn infants with respiratory distress: Echo-doppler study. J Pediatr 1987; 110(5): 760-4.
[http://dx.doi.org/10.1016/S0022-3476(87)80020-3] [PMID: 3572630]
[70]
Lavie CJ, Hebert K, Cassidy M. Prevalence and severity of Doppler-detected valvular regurgitation and estimation of right-sided cardiac pressures in patients with normal two-dimensional echocardiograms. Chest 1993; 103(1): 226-31.
[http://dx.doi.org/10.1378/chest.103.1.226] [PMID: 8417884]
[71]
Messing B, Porat S, Imbar T, Valsky DV, Anteby EY, Yagel S. Mild tricuspid regurgitation: A benign fetal finding at various stages of pregnancy. Ultrasound Obstet Gynecol 2005; 26(6): 606-10.
[http://dx.doi.org/10.1002/uog.1999] [PMID: 16211645]
[72]
Gembruch U, Smrcek JM. The prevalence and clinical significance of tricuspid valve regurgitation in normally grown fetuses and those with intrauterine growth retardation. Ultrasound Obstet Gynecol 1997; 9(6): 374-82.
[http://dx.doi.org/10.1046/j.1469-0705.1997.09060374.x] [PMID: 9239822]
[73]
Mäkikallio K, Jouppila P, Räsänen J. Retrograde net blood flow in the aortic isthmus in relation to human fetal arterial and venous circulations. Ultrasound Obstet Gynecol 2002; 19(2): 147-52.
[http://dx.doi.org/10.1046/j.0960-7692.2001.00626.x] [PMID: 11876806]
[74]
Gardiner HM. Response of the fetal heart to changes in load: From hyperplasia to heart failure. Heart 2005; 91(7): 871-3.
[http://dx.doi.org/10.1136/hrt.2004.047399] [PMID: 15958350]
[75]
Ouzounian JG, Hernandez GD, Korst LM, et al. Pre-pregnancy weight and excess weight gain are risk factors for macrosomia in women with gestational diabetes. J Perinatol 2011; 31(11): 717-21.
[http://dx.doi.org/10.1038/jp.2011.15] [PMID: 21372797]
[76]
Metzger BE, Lowe LP, Dyer AR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008; 358(19): 1991-2002.
[http://dx.doi.org/10.1056/NEJMoa0707943] [PMID: 18463375]
[77]
Walton JR, Peaceman AM. Identification, assessment and management of fetal compromise. Clin Perinatol 2012; 39(4): 753-68.
[http://dx.doi.org/10.1016/j.clp.2012.09.001] [PMID: 23164176]
[78]
Gagnon R, Harding R, Brace RA. Amniotic fluid and fetal urinary responses to severe placental insufficiency in sheep. Am J Obstet Gynecol 2002; 186(5): 1076-84.
[http://dx.doi.org/10.1067/mob.2002.122291] [PMID: 12015540]
[79]
Choi SR. Borderline amniotic fluid index and perinatal outcomes in the uncomplicated term pregnancy. J Matern Fetal Neonatal Med 2016; 29(3): 457-60.
[http://dx.doi.org/10.3109/14767058.2015.1004051] [PMID: 25626056]
[80]
Banks EH, Miller DA. Perinatal risks associated with borderline amniotic fluid index. Am J Obstet Gynecol 1999; 180(6): 1461-3.
[http://dx.doi.org/10.1016/S0002-9378(99)70037-2] [PMID: 10368489]
[81]
Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308(5728): 1592-4.
[http://dx.doi.org/10.1126/science.1111726] [PMID: 15947178]
[82]
Zhong Y, Tuuli M, Odibo AO. First-trimester assessment of placenta function and the prediction of preeclampsia and intrauterine growth restriction. Prenat Diagn 2010; 30(4): 293-308.
[http://dx.doi.org/10.1002/pd.2475] [PMID: 20166149]
[83]
Roozbeh N, Azizi M, Darvish L. Pregnancy outcome of abnormal nuchal translucency: A systematic review. J Clin Diagn Res 2017; 11(3): QC12-6.
[http://dx.doi.org/10.7860/JCDR/2017/23755.9384] [PMID: 28511453]
[84]
Bottomley C, Van Belle V, Mukri F, et al. The optimal timing of an ultrasound scan to assess the location and viability of an early pregnancy. Hum Reprod 2009; 24(8): 1811-7.
[http://dx.doi.org/10.1093/humrep/dep084] [PMID: 19363041]
[85]
Snijders RJM, Noble P, Sebire N, Souka A, Nicolaides KH. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10–14 weeks of gestation. Lancet 1998; 352(9125): 343-6.
[http://dx.doi.org/10.1016/S0140-6736(97)11280-6] [PMID: 9717920]
[86]
Van Mieghem T, Hindryckx A, Van Calsteren K. Early fetal anatomy screening. Curr Opin Obstet Gynecol 2015; 27(2): 143-50.
[http://dx.doi.org/10.1097/GCO.0000000000000161] [PMID: 25689240]
[87]
Iliescu D, Tudorache S, Comanescu A, et al. Improved detection rate of structural abnormalities in the first trimester using an extended examination protocol. Ultrasound Obstet Gynecol 2013; 42(3): 300-9.
[http://dx.doi.org/10.1002/uog.12489] [PMID: 23595897]
[88]
Hsiao CH, Cheng PJ, Shaw SWS, et al. Extended first-trimester screening using multiple sonographic markers and maternal serum biochemistry: A five-year prospective study. Fetal Diagn Ther 2014; 35(4): 296-301.
[http://dx.doi.org/10.1159/000357564] [PMID: 24503519]
[89]
Mulvey S, Wallace EM. Women’s knowledge of and attitudes to first and second trimester screening for Down’s syndrome. BJOG 2000; 107(10): 1302-5.
[http://dx.doi.org/10.1111/j.1471-0528.2000.tb11624.x] [PMID: 11028585]
[90]
Abu-Rustum RS, Ziade MF, Abu-Rustum SE. Learning curve and factors influencing the feasibility of performing fetal echocardiography at the time of the first-trimester scan. J Ultrasound Med 2011; 30(5): 695-700.
[http://dx.doi.org/10.7863/jum.2011.30.5.695] [PMID: 21527618]
[91]
Molina GFS, Carrillo BMP, Zaragoza GEA, Fernández de Santos AG, Montoya VF. Analysis of secondary ultrasound markers in the first trimester before chorionic villus sampling. Prenat Diagn 2010; 30(12-13): 1117-20.
[http://dx.doi.org/10.1002/pd.2615] [PMID: 20949642]
[92]
Respondek ML, Kammermeier M, Ludomirsky A, Weil SR, Huhta JC. The prevalence and clinical significance of fetal tricuspid valve regurgitation with normal heart anatomy. Am J Obstet Gynecol 1994; 171(5): 1265-70.
[http://dx.doi.org/10.1016/0002-9378(94)90144-9] [PMID: 7977531]
[93]
Brestak M, Calda P, McKenna D, Sonek J. Comparison of right ventricular measurements and SFRV in fetuses with and without tricuspid regurgitation at 11 + 0 and 13 + 6 weeks’ gestation. J Matern Fetal Neonatal Med 2014; 27(15): 1531-4.
[http://dx.doi.org/10.3109/14767058.2013.863867] [PMID: 24195656]
[94]
Chanprapaph P, Dulyakasem C, Phattanchindakun B. Sensitivity of multiple first trimester sonomarkers in fetal aneuploidy detection. J Perinat Med 2015; 43(3): 359-65.
[http://dx.doi.org/10.1515/jpm-2014-0201] [PMID: 25222592]
[95]
Zournatzi V, Daniilidis A, Karidas C, Tantanasis T, Loufopoulos A, Tzafettas J. A prospective two years study of first trimester screening for Down syndrome. Hippokratia 2008; 12(1): 28-32.
[PMID: 18923756]
[96]
DeVore GR. Trisomy 21: 91% detection rate using second-trimester ultrasound markers. Ultrasound Obstet Gynecol 2000; 16(2): 133-41.
[http://dx.doi.org/10.1046/j.1469-0705.2000.00203.x] [PMID: 11117082]
[97]
Li Y, Hua Y, Fang J, et al. Performance of different scan protocols of fetal echocardiography in the diagnosis of fetal congenital heart disease: A systematic review and meta-analysis. PLoS One 2013; 8(6): e65484.
[http://dx.doi.org/10.1371/journal.pone.0065484] [PMID: 23750263]
[98]
Zidere V, Bellsham-Revell H, Persico N, Allan LD. Comparison of echocardiographic findings in fetuses at less than 15 weeks’ gestation with later cardiac evaluation. Ultrasound Obstet Gynecol 2013; 42(6): 679-86.
[http://dx.doi.org/10.1002/uog.12517] [PMID: 23703918]
[99]
Syngelaki A, Chelemen T, Dagklis T, Allan L, Nicolaides KH. Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11-13 weeks. Prenat Diagn 2011; 31(1): 90-102.
[http://dx.doi.org/10.1002/pd.2642] [PMID: 21210483]
[100]
Bellotti M, Fesslova V, De Gasperi C, et al. Reliability of the first-trimester cardiac scan by ultrasound-trained obstetricians with high-frequency transabdominal probes in fetuses with increased nuchal translucency. Ultrasound Obstet Gynecol 2010; 36(3): 272-8.
[http://dx.doi.org/10.1002/uog.7685] [PMID: 20499407]
[101]
Herrera TT, Sinisterra S, Solis A, Britton GB. First trimester screening using ultrasound and serum markers in panamanians: Factors associated with adverse pregnancy outcomes. J Res Med Sci 2014; 19(5): 451-6.
[PMID: 25097629]

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