Generic placeholder image

Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Severe Thromboses in Neonates

Author(s): Matthew A. Saxonhouse* and Ashley Hinson

Volume 19, Issue 4, 2023

Published on: 15 December, 2022

Page: [366 - 370] Pages: 5

DOI: 10.2174/1573396319666221124121815

Price: $65


Severe thrombosis in the neonate presents a diagnostic challenge to the clinician as the benefits and risks for treatment must be weighed with every medical decision. Aortic thromboses, large right atrial thromboses, and septic thrombophlebitis present unique clinical challenges that must be managed in the appropriate clinical setting with appropriate subspecialty support. Unfortunately, there is limited data on what the ideal therapy should be for these specific types of cases. In this review, we will discuss these types of severe thromboses that may occur in neonates and potential therapies that may offer benefits.

Keywords: Thrombosis, neonate, diagnostic challenge, clinician thrombophlebitis, thromboses, anticoagulant.

Graphical Abstract
Nowak-Göttl U, von Kries R, Göbel U. Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed 1997; 76(3): F163-7.
[] [PMID: 9175945]
van Ommen CH, Heijboer H, Büller HR, Hirasing RA, Heijmans HSA, Peters M. Venous thromboembolism in childhood: A prospective two-year registry in The Netherlands. J Pediatr 2001; 139(5): 676-81.
[] [PMID: 11713446]
Uttara N. Risk factors for thrombosis in the neonatal intensive care unit: Analysis of large national database. 2017.Available from.
Saracco P, Bagna R, Gentilomo C, et al. Clinical data of neonatal systemic thrombosis. J Pediatr 2016; 171: 60-66.e1.
[] [PMID: 26787378]
Saxonhouse MA. Thrombosis in the neonatal intensive care unit. Clin Perinatol 2015; 42(3): 651-73.
[] [PMID: 26250924]
Thay WY, Aisha Fadhilah AA, Faizah MJ, Zainudin Z. Neonatal aortic thrombosis: A life threatening complication of umbilical artery catheterisation. Med J Malaysia 2020; 75(2): 173-4.
[PMID: 32281603]
Gürsu HA, Varan B, Oktay A, Özkan M. A case of neonatal arterial thrombosis mimicking interrupted aortic arch. Turk Pediatri Ars 2015; 50(2): 118-22.
[] [PMID: 26265897]
Bhat R, Monagle P. The preterm infant with thrombosis. Arch Dis Child Fetal Neonatal Ed 2012; 97(6): F423-8.
[] [PMID: 22562868]
Schmidt B, Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 1995; 96(5): 939-43.
[] [PMID: 7478839]
Nagel K, Tuckuviene R, Paes B, Chan A. Neonatal aortic thrombosis: a comprehensive review. Klin Padiatr 2010; 222(3): 134-9.
[] [PMID: 20514615]
Francis JV, Monagle P, Hope S, Sehgal A. Occlusive aortic arch thrombus in a preterm neonate. Pediatr Crit Care Med 2010; 11(1): e13-5.
[] [PMID: 20051786]
Gaur S, Saxonhouse M, Hinson A. Creation of a neonatal thrombosis center and its use to successfully treat infants with severe throm-bosis. Global J Pediatr Neonat Care 2021; 3(2): 1-10.
Saxonhouse MA, Sola-Visner M. Platelets and disorders of coagulation. In: Kluwer Wolters, Ed. Avery and MacDonalds Neonatology Pathophysiology and Management of the Newborn. (8th ed.), The Netherlands 2021.
Baykan A, Ozyurt A, Korkmaz L, et al. Giant right atrial thrombus in premature newborn. J Thromb Thrombolysis 2014; 37(3): 353-5.
[] [PMID: 23689956]
Ulloa-Ricardez A, Romero-Espinoza L, de Jesús Estrada-Loza M, et al. Risk factors for intracardiac thrombosis in the right atrium and superior vena cava in critically Ill neonates who required the installation of a central venous catheter. Pediatr Neonatol 2015; 57(4): 288-94.
[PMID: 26747618]
Yang JYK, Williams S, Brandão LR, Chan AKC. Neonatal and childhood right atrial thrombosis: recognition and a risk-stratified treatment approach. Blood Coagul Fibrinolysis 2010; 21(4): 301-7.
[] [PMID: 20305543]
Yang JYK, Williams S, Brandão LR, Chan AKC, Mondal T. Neonatal and childhood right atrial thrombosis. Blood Coagul Fibrinolysis 2013; 24(4): 458.
[] [PMID: 23632382]
Carlson JA, Chen KR. Cutaneous vasculitis update: small vessel neutrophilic vasculitis syndromes. Am J Dermatopathol 2006; 28(6): 486-506.
[] [PMID: 17122493]
Ackerman A. Specific diagnosis; septic vasculitisHistologic Diagnosis of Inflammatory Skin Disease An Algorithmic Method Based on Pattern Analysis. (2nd ed.). Baltimore: Williams & Wilkins 1997; pp. 727-8.
Valerio L, Riva N. Head, Neck, and abdominopelvic septic thrombophlebitis: current evidence and challenges in diagnosis and treatment. Hamostaseologie 2020; 40(3): 301-10.
[] [PMID: 32726825]
Delgado-Jiménez Y, Fraga J, Requena C, et al. Acute bacterial septic vasculopathy. Int J Dermatol 2013; 52(9): 1071-80.
[] [PMID: 23231414]
Dix D, Andrew M, Marzinotto V, et al. The use of low molecular weight heparin in pediatric patients: A prospective cohort study. J Pediatr 2000; 136(4): 439-45.
[] [PMID: 10753240]
Sanchez de Toledo J, Gunawardena S, Munoz R, et al. Do neonates, infants and young children need a higher dose of enoxaparin in the cardiac intensive care unit? Cardiol Young 2010; 20(2): 138-43.
[] [PMID: 20199704]
Monagle P, Chan AKC, Goldenberg NA, et al. Antithrombotic therapy in neonates and children. Chest 2012; 141 (Suppl. 2): e737S-801S.
[] [PMID: 22315277]
Koo J, Pong A, Dory C, Farnaes L, Thornburg CD. Management and outcomes of pediatric septic thrombophlebitis: a case series. Pediatr Hematol Oncol 2020; 37(4): 344-52.
[] [PMID: 32138584]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy