Title:Vaccines: An Important Tool for Infectious Disease
Volume: 18
Issue: 2
Author(s): Saika Saman, Iti Chauhan and Nimisha Srivastava*
Affiliation:
- Department of Pharmaceutics, Faculty of Pharmacy, Amity Institute of Pharmacy, Amity University,
Lucknow, Uttar Pradesh, Sector 125, Noida 201313, India
Keywords:
Vaccination, immune, immunity, antigens, disease, vaccine delivery.
Abstract:
Vaccines are usually regarded as one of the most important tools in the battle
against infectious diseases. Even though currently accessible vaccinations are an incredible
success story in contemporary medicine and have had a significant impact on global
morbidity and death rates, it is evident that current vaccine delivery approaches need to
be improved. To allow the successful creation of vaccinations against contagious diseases
that have proven challenging to manage with conventional procedures, improvements
are necessary. Improvements could include the introduction of innovative injectable adjuvants
or novel delivery methods, such as mucosal immunization. Protection against infections
that infect mucosal areas may necessitate mucosal delivery.
Alternatively, innovative techniques for delivery, such as intradermal administration using
self-administrable devices or the use of microneedle technology to bypass the stratum
corneum's skin penetration barrier and aid in the transport of antigens, could be utilized
to increase vaccine compliance. Needle-free delivery systems are of particular relevance
for safer mass immunization programs, as they would prevent problems caused by needles
reuse in several regions of the world, as well as needle-stick accidents.
Based on this information, future vaccine development will mainly concentrate on rational
antigen, adjuvant, and, most importantly, delivery mechanism design, resulting in
new and improved vaccinations.
In addition, this study discusses the current state and prospects of vaccine delivery via a
variety of channels, including non- or minimally invasive approaches.
