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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Online): 2212-3873

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Review Article

Natural Bioactive Compounds against Oxidative Stress: Dietary Polyphenols Strike Back

Author(s): Roberto Arrigoni, Francesco Cammarota, Rosa Porro, Stefania Cantore*, Mario Dioguardi, Angela Pia Cazzolla, Francesco De Leonardis, Lorenzo Polimeno, Nicoletta Zerman, Michele Di Cosola, Filiberto Mastrangelo, Luigi Santacroce and Andrea Ballini

Volume 23, Issue 6, 2023

Published on: 06 January, 2023

Page: [764 - 776] Pages: 13

DOI: 10.2174/1871530323666221107092553

Price: $65

Abstract

Oxidative stress is a major cellular and metabolic burden that can really alter cell life and become the base for disease onset and development. Many widespread pathologies can develop from an unresolved oxidative stress situation; thus, addressing this state is paramount for human health. Our antioxidant enzymes sometimes are not just enough. Fortifying our defense and the antioxidant and anti-inflammatory system can make a difference in our health: if this is attainable with our dietary habits, it could be a dream come true. Polyphenols are a fantastic tool indeed in the fight against oxidative stress: they are easy to obtain, with little cost, no side effects, and have a multitude of metabolic actions. This perspective review would shed light on polyphenol’s metabolic and molecular action regarding oxidative stress to help preserve our health.

Keywords: Polyphenols, oxidative stress, natural compounds, anti-inflammatory activity, reactive oxygen species (ROS), polyphenol therapeutic potential, clinical studies.

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