Title:Current Status on 1,4-Dihydropyridine Derivatives against Human
Pathogenic Parasites
Volume: 30
Issue: 15
Author(s): Orlando Elso, Guadalupe García Liñares*Valeria Sülsen
Affiliation:
- Laboratorio de Biocatálisis, Departamento
de Química Orgánica y UMYMFOR, Facultad de Ciencias Exactas y Naturales, Universidad de
Buenos Aires, Ciudad Universitaria, Pabellón 2, piso 3, C1428EGA, Buenos Aires, Argentina
Keywords:
Dihydropyridine, trypanosomiasis, malaria, leishmaniasis, parasitic diseases, chemotherapy.
Abstract: Infections provoked by parasites are among the most prevalent diseases worldwide
and generate important health and socioeconomic problems. Despite the enormous
amount of work done, the chemotherapy for most of them remains unsolved. Usually,
treatments are based on no specific drugs associated, in several cases, with long-term
treatments and severe side effects. In addition, drug resistance and different strains' susceptibility
are further drawbacks of the existing chemotherapy. Considering that 1,4-dihydropyridines
derivatives constitute an important class of compounds for new drug development,
we present in this review an in-depth overview of the work done so far on 1,4-dihydropyridines
and their antiparasitic activities. The development of new derivatives or
the application of known drugs used for other diseases is described in terms of their potential
usefulness for drug design.