Title:Recent Advances: From Cell Biology to Cell Therapy in Atherosclerosis
Plaque via Stent Implantation
Volume: 30
Issue: 31
Author(s): Sainan Liu, Li Li, Huanran Wang, Jianying Tan, Lai Wei, Yajun Weng and Junying Chen*
Affiliation:
- Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China
Keywords:
Atherosclerosis, endothelial cell, smooth muscle cell, macrophage, foam cell, stent.
Abstract: Atherosclerosis is a multifactorial result of complicated pathophysiology.
Changes in the expression of polygenes, coupled with environmental and lifestyle factors,
trigger a cascade of adverse events involving a variety of cell types, such as vascular endothelial
cells, smooth muscle cells, and macrophages. In this review, we summarize the
function and therapeutic targets of atherosclerotic cells. This article reviews the role of
endothelial cells, smooth muscle cells, macrophages and foam cells in the development of
atherosclerosis and the progress in the treatment of atherosclerosis by targeting these cells.
Atherosclerotic plaque involves a variety of cells and biomolecules, and its complex biological
environment is a difficult point for the study and treatment of atherosclerosis. For
treating atherosclerosis, a large number of studies emerged based on blocking or inhibiting
factors affecting the formation and development of plaque. Cardiovascular stent intervention
is currently the main method for the treatment of atherosclerosis. In recent decades,
numerous studies on cardiovascular, stents mainly involve drug coating or biomolecular
modification of stents to enhance anti-thrombosis, anti-restenosis and endothelialization.
This paper introduces the research status of cardiovascular stents and new
strategies for surface modification. The treatment of atherosclerosis based on the level of
molecular biology and cell biology is becoming a research hotspot in the coming decades.