Title:A Systematic Review of the Therapeutic Potential of Resveratrol During
Colorectal Cancer Chemotherapy
Volume: 23
Issue: 10
Author(s): Xiao-Yu Wu, Jing Zhai, Xiang- Kun Huan, Wen-Wen Xu*, Jun Tian*Bagher Farhood*
Affiliation:
- Department of Gynaecology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing
Jiangsu, 210029, China
- Department of General Surgery, Zhangjiagang Hospital of Traditional Chinese Medicine,
Suzhou Jiangsu, 215600, China
- Department of Medical Physics and Radiology, Faculty of Paramedical Sciences,
Kashan University of Medical Sciences, Kashan, Iran
Keywords:
Colorectal cancer, chemotherapy, chemosensitizer, resveratrol, systemic review, chemotherapy drugs.
Abstract:
Background: The chemotherapy modality is generally used for treating colorectal cancer.
However, the clinical application of chemotherapeutic drugs may be limited due to their adverse
effects on normal cells/tissues and the development of cancer resistance. Using the combined
treatment of chemotherapy drugs and natural bioactive compounds (such as resveratrol) can
alleviate adverse drug reactions and induce synergies between the drugs.
Objective: In the current review, the potential therapeutic impacts of resveratrol during colorectal
cancer chemotherapy were studied.
Methods: Based on the PRISMA guideline, we performed a systematic search in different electronic
databases up to May, 2021. Following the search, 321 papers were found and then screened
for eligibility. Twenty-seven papers were finally included in the present study
Results: Compared to the control group, the growth inhibition of cancerous cells treated with
chemotherapeutic drugs was considerably higher, and resveratrol co-administration synergistically
increased chemotherapy-induced cytotoxicity. Moreover, a reduction in the tumor weight, volume
and growth of mice was observed following chemotherapy administration compared to the untreated
groups, and these reductions were predominant in animals treated with resveratrol plus chemotherapy.
Other findings showed that chemotherapy alone and in combination with resveratrol modulated
the cell cycle profile of cancerous cells. Furthermore, chemotherapy treatment induced a set of biochemical
and histopathological alterations in cancer cells/tissues, and these changes were synergized
following resveratrol co-treatment (in most of the cases), excluding inflammatory mediators.
Conclusion: In most cases, resveratrol co-administration could sensitize cancerous cells to chemotherapy
drugs through its oxidant, apoptosis, anti-inflammatory activities, etc. Nevertheless, suggesting the
use of resveratrol during chemotherapy of colorectal cancer patients requires further clinical studies.
