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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Systematic Review Article

Anti-Toxoplasma gondii Activity of Curcumin: A Systematic Review of Pre-clinical Studies

Author(s): Hamed Kalani, Pegah Shakib, Roghiyeh Faridnia, Jeffery Ho, Omid Mardanshah, Mehrdad Dolatshah, Asghar Sepahvand, Kourosh Cheraghipour* and Masoomeh Zivdaria

Volume 23, Issue 2, 2023

Published on: 20 October, 2022

Article ID: e200822207821 Pages: 5

DOI: 10.2174/1871526522666220820185637

Price: $65

Abstract

Objective: This study has focused on anti-Toxoplasma gondii activity of curcumin.

Methods: In this systematic review, anti-parasitic activity of Curcuma longa on Toxoplasma gondii was assessed. Therefore, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar, were searched from 2010 to 2020.

Results: Of the 2200 papers retrieved between 2010 and 2020, six articles were reliable and were scrutinized. In 2 in vitro studies, the most used strain was the RH strain of Toxoplasma gondii, whereas among 4 in vivo studies, RH strain was found in 2 (50%) studies, Me49 strain in 1(25%) study, and RH and Me49 strain in 1 (25%) study. In four in vivo studies, the most used animal model was BALB/c, and Swiss albino was found in 1 study (25%) and Albino rats in 1 study (25%).

Conclusion: Curcumin and nanoparticles formulated with curcumin are new and useful agents for the treatment of parasitic diseases and reduction of drug resistance. The success of this therapeutic approach stems from the specific action of Curcuma longa against parasites and pathogens.

Keywords: Toxoplasma gondii, Curcuma longa, parasitic activity, pre-clinical studies, curcumin, systematic review.

Graphical Abstract
[1]
Bennett JE, Dolin R, Blaser MJ. Mandell, douglas, and bennett’s principles and practice of infectious diseases. Elsevier 2014; 1: p. 3697.
[2]
Chambers H, Jawetz E. Sulfonamides, trimethoprim and quinolones. In: Basic &. Clin Pharmacol 2004; 8: 793-802.
[3]
Zargari A. Medicinal plants. Tehran: Tehran Univ 1997.
[4]
Thiengsusuk A, Chaijaroenkul W, Na-Bangchang K. Antimalarial activities of medicinal plants and herbal formulations used in Thai tradi-tional medicine. Parasitol Res 2013; 112(4): 1475-81.
[http://dx.doi.org/10.1007/s00436-013-3294-6] [PMID: 23340720]
[5]
Cheraghipour K, Masoori L, Ezzatpour B, et al. The experimental role of medicinal plants in treatment of Toxoplasma gondii infection: A systematic review. Acta Parasitol 2021; 66(2): 303-28.
[http://dx.doi.org/10.1007/s11686-020-00300-4] [PMID: 33159263]
[6]
Cheraghipour K, Beiranvand M, Zivdari M, et al. In vitro potential effect of Pipper longum methanolic extract against protoscolices of hydatid cysts. Exp Parasitol 2021; 221: 108051.
[http://dx.doi.org/10.1016/j.exppara.2020.108051] [PMID: 33301754]
[7]
Mahmoudvand H, Fasihi Harandi M, Shakibaie M, et al. Scolicidal effects of biogenic selenium nanoparticles against protoscolices of hydatid cysts. Int J Surg 2014; 12(5): 399-403.
[http://dx.doi.org/10.1016/j.ijsu.2014.03.017] [PMID: 24686032]
[8]
Aggarwal BB, Surh YJ, Shishodia S. The molecular targets and therapeutic uses of curcumin in health and disease. Springer Science & Business Media 2007.
[http://dx.doi.org/10.1007/978-0-387-46401-5]
[9]
Tønnesen HH, Karlsen J. Studies on curcumin and curcuminoids. VI. Kinetics of curcumin degradation in aqueous solution. Z Lebensm Unters Forsch 1985; 180(5): 402-4.
[PMID: 4013525]
[10]
Jacob A, Wu R, Zhou M, Wang P. Mechanism of the anti-inflammatory effect of curcumin: PPAR-γ activation. PPAR Res 2007; 2007: 89369.
[http://dx.doi.org/10.1155/2007/89369] [PMID: 18274631]
[11]
Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: A review of anticancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 2011; 10: 12.
[http://dx.doi.org/10.1186/1476-4598-10-12] [PMID: 21299897]
[12]
Cheraghipour K, Marzban A, Ezatpour B, Khanizadeh S, Koshki J. Antiparasitic properties of curcumin: A review. AIMS Agric Food 2018; 3(4): 561-78.
[13]
Strimpakos AS, Sharma RA. Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 2008; 10(3): 511-45.
[http://dx.doi.org/10.1089/ars.2007.1769] [PMID: 18370854]
[14]
Wang S, Su R, Nie S, et al. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem 2014; 25(4): 363-76.
[http://dx.doi.org/10.1016/j.jnutbio.2013.10.002] [PMID: 24406273]
[15]
Pinto JG, Fontana LC, de Oliveira MA, Kurachi C, Raniero LJ, Ferreira-Strixino J. In vitro evaluation of photodynamic therapy using curcumin on Leishmania major and Leishmania braziliensis. Lasers Med Sci 2016; 31(5): 883-90.
[http://dx.doi.org/10.1007/s10103-016-1928-5] [PMID: 27056699]
[16]
Cui L, Miao J, Cui L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: Inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 2007; 51(2): 488-94.
[http://dx.doi.org/10.1128/AAC.01238-06] [PMID: 17145789]
[17]
Mahmoudvand H, Pakravanan M, Aflatoonian MR, et al. Efficacy and safety of Curcuma longa essential oil to inactivate hydatid cyst protoscoleces. BMC Complement Altern Med 2019; 19(1): 187.
[http://dx.doi.org/10.1186/s12906-019-2527-3] [PMID: 31349828]
[18]
Cheraghipour K, Ezatpour B, Masoori L, et al. Anticandida activity of curcumin: A systematic review. Curr Drug Discov Technol 2021; 18(3): 379-90.
[http://dx.doi.org/10.2174/1570163817666200518074629] [PMID: 32418527]
[19]
Saki J, Sabaghan M, Arjmand R, et al. Curcumin as an indirect methylation inhibitor modulates the effects of Toxoplasma gondii on genes involved in male fertility. EXCLI J 2020; 19: 1196-207.
[PMID: 33013270]
[20]
Goo YK, Yamagishi J, Ueno A, et al. Characterization of Toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures. Parasit Vectors 2015; 8: 654.
[http://dx.doi.org/10.1186/s13071-015-1268-5] [PMID: 26694921]
[21]
El-Shafey AAM, Hegab MHA, Seliem MME, et al. Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis. J Mater Sci Mater Med 2020; 31(11): 90.
[http://dx.doi.org/10.1007/s10856-020-06429-y] [PMID: 33089411]
[22]
Azami SJ, Teimouri A, Keshavarz H, et al. Curcumin nanoemulsion as a novel chemical for the treatment of acute and chronic toxoplasmosis in mice. Int J Nanomedicine 2018; 13: 7363-74.
[http://dx.doi.org/10.2147/IJN.S181896] [PMID: 30519020]
[23]
Moawad MAF, Amin MM, Hafez EN. Vaccination with irradiated tachyzoites show better therapeutic effect than some plants or drugs on toxoplasmosis. Pak J Zool 2016; 48(1): 241-8.
[24]
Simanjuntak TP, Hatta M, Tahir AM, et al. Analysis of anti-toxoplasma immunoglobulin G and immunoglobulin M antibody levels after intervention with Curcuma longa extract on early pregnant mice with acute toxoplasmosis. J Glob Infect Dis 2019; 11(1): 25-9.
[http://dx.doi.org/10.4103/jgid.jgid_28_18] [PMID: 30814832]
[25]
Faucher B, Moreau J, Zaegel O, Franck J, Piarroux R. Failure of conventional treatment with pyrimethamine and sulfadiazine for secondary prophylaxis of cerebral toxoplasmosis in a patient with AIDS. J Antimicrob Chemother 2011; 66(7): 1654-6.
[http://dx.doi.org/10.1093/jac/dkr147] [PMID: 21459896]
[26]
Crespo M, Quereda C, Pascual J, Rivera M, Clemente L, Cano T. Patterns of sulfadiazine acute nephrotoxicity. Clin Nephrol 2000; 54(1): 68-72.
[PMID: 10939760]
[27]
Djurković-Djaković O, Nikolić T, Robert-Gangneux F, Bobić B, Nikolić A. Synergistic effect of clindamycin and atovaquone in acute murine toxoplasmosis. Antimicrob Agents Chemother 1999; 43(9): 2240-4.
[http://dx.doi.org/10.1128/AAC.43.9.2240] [PMID: 10471572]
[28]
Dunay IR, Heimesaat MM, Bushrab FN, et al. Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis. Antimicrob Agents Chemother 2004; 48(12): 4848-54.
[http://dx.doi.org/10.1128/AAC.48.12.4848-4854.2004] [PMID: 15561866]
[29]
Hughes LM, Lanteri CA, O’Neil MT, Johnson JD, Gribble GW, Trumpower BL. Design of anti-parasitic and anti-fungal hydroxynaphthoquinones that are less susceptible to drug resistance. Mol Biochem Parasitol 2011; 177(1): 12-9.
[http://dx.doi.org/10.1016/j.molbiopara.2011.01.002] [PMID: 21251932]
[30]
Song P, Zhang R, Wang X, He P, Tan L, Ma X. Dietary grapeseed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats. J Agric Food Chem 2011; 59(11): 6227-32.
[http://dx.doi.org/10.1021/jf200120y] [PMID: 21534629]
[31]
Kheirandish F, Marzban A, Masoori L, Nourmohammadi M, Moradpour K. Efficacy of thymol on the scolices of hydatid cyst. Herb Med J 2020; 5(1): 1-8.
[32]
Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem 2007; 102(4): 1095-104.
[http://dx.doi.org/10.1111/j.1471-4159.2007.04613.x] [PMID: 17472706]
[33]
Vogel A, Pelletier J. Examen chimique de la racine de Curcuma. J Pharm (Cairo) 1815; 1: 289-300.
[34]
Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol 2012; 39(3): 283-99.
[http://dx.doi.org/10.1111/j.1440-1681.2011.05648.x] [PMID: 22118895]

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