Title:Gd-EOB-DTPA Enhanced MRI Features of Liver Hemangiomatosis
Coexistent with GCH
Volume: 18
Author(s): Dong Liu, Zhenguo Qiao, Lihua Xu, Fangfang Fu, Aihua Ye*Chunhong Hu*
Affiliation:
- Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China
Keywords:
Hepatic, hemangiomatosis, magnetic resonance imaging, gadolinium-ethoxybenzyl-diethylenetriamin-pentaacetic acid, diagnosis, imaging.
Abstract:
Objectives: This study aimed to clarify features of giant cavernous hemangioma (GCH) and
liver hemangiomatosis, existing simultaneously on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic
acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI).
Method: A total of 17 patients with reported hepatic hemangiomatosis between 2015 and 2017 were
identified retrospectively. All our patients underwent pre-contrast MRI, triphasic (atrial, portal, venous)
Gd-EOB-DTPA dynamic enhancement and hepatobiliary phase (20 minutes delayed). The location,
size, morphology and signal characteristics on T1-weighted (T1WI) and T2-weighted images
(T2WI), and Gd-EOB-DTPA-enhanced MRI of liver hemangiomatosis were evaluated.
Results: Hemangiomatosis involved the liver adjacent to the edge of the GCH with no normal liver
tissue found in 13 cases; in the other 4 patients, a small area of normal liver tissue separated GCH from
hemangiomatosis was seen. On non-contrast MRI images, hemangionmatosis presented as numerous
microcystic lesions, with low signal intensity on T1WI and high signal intensity on T2WI, compared
with unaffected liver. After administration of Gd-EOB-DTPA, heterogeneous enhancement was presented
in the arterial phase, during portal and venous phase imaging, becoming more homogeneous. 11
cases showed hypointensity in the hepatobiliary phase (6 cases with intratumor necrosis), and 6 cases
showed hyper-intensity in the hepatobiliary phase with a remaining unfilled portion.
Conclusion: Hemangiomatosis is extremely rare in the liver adjacent to a GCH. MRI is of great diagnostic
and clinical value for this kind of tumor according to the configuration, size, signal, and style of
enhancement, but the final diagnosis depends on pathology. Gd-EOB-DTPA-enhanced MRI may help
in diagnosing hemangiomatosis coexistent with GCH.