HERVs Role in the Pathogenesis, Diagnosis or Prognosis of Aging
Diseases: A Systematic Review

Paula      Prieto-Oliveira
doi:10.2174/1566524022666220525144135
Abstract

Introduction: HERVs are human endogenous retroviruses, which represent about 8% of the human genome, and have various physiological functions, especially in pregnancy, embryo development and placenta formation. However, their involvement in diseases is not well defined. Some studies have observed changes in HERV expression according to age.
Objective: Therefore, the aim of this systematic review was to analyze their role in pathogenesis and usage as diagnosis or prognosis biomarkers in aging disorders.
Methods: In this study, a search on the Pubmed interface was performed for papers published from January 1953 to June 1^st, 2021.
Results: 45 articles have been included, which matched the eligibility criteria and evaluated the following diseases: breast cancer, prostate cancer, amyotrophic lateral sclerosis (ALS), osteoarthritis, Alzheimer's disease, immuno-senescence, cognitive impairment, cataract, glaucoma and hypertension.
Conclusion: In conclusion, the results suggested that HERVs play a role in the pathogenesis and can be used as biomarkers for the diagnosis or prognosis of aging disorders.
Keywords: HERVs, ERVs, endogenous retroviruses, aging, senescence, disease.
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DOI https://dx.doi.org/10.2174/1566524022666220525144135	Print ISSN 1566-5240
Publisher Name Bentham Science Publisher	Online ISSN 1875-5666
Current Molecular Medicine

HERVs Role in the Pathogenesis, Diagnosis or Prognosis of Aging Diseases: A Systematic Review

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Molecular and Cellular Mechanisms in Vertigo / Vestibular Disorders

Current Molecular Medicine

HERVs Role in the Pathogenesis, Diagnosis or Prognosis of Aging Diseases: A Systematic Review

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