Background: Mucormycosis is a genuine, however uncommon shrewd fungal contamination that spreads quickly, and subsequently brief analysis and treatment are important to stay away from the high pace of mortality and morbidity rates. Mucormycosis is brought about by the inward breath of its filamentous (hyphal structure) fungus, particularly in immunosuppressed patients. The pandemic of COVID -19 stays on an upsurge pattern. The second rush of this infection has prompted alarm in numerous nations, including India and a few pieces of the world experiencing the third wave. As there could be no appropriate treatment choices or cures accessible for this lethal contamination, steady consideration gears like oxygen chambers, ventilators and substantial utilization of steroids assume an imperative part in the management of COVID-19. Amidst this pandemic, the COVID-19 patients are procuring optional contaminations, for example, mucormycosis otherwise called black fungus infection.
Objective: It is important to lead research on COVID-19 patients to even more likely to forestall and oversee pioneering contaminations to diminish their occurrence and bleakness. So, this paper is to foster preventive treatment plans and use corticosteroids sanely.
Methods: Using search engines like Embase, PubMed, Google Scholar, etc., various research, review articles, and some book chapters, also various articles on websites and guidelines on the ICMR portal were accessed, after which we prepared this review article. In this review, we have included reported cases and case series of mucormycosis among patients with and without COVID-19 spanning the period of 1969 to 2021 and have described the clinical features and outcomes.
Results: In gentle instances of COVID-19 (without hypoxemia) or when utilizing higher dosages of glucocorticoids, glucocorticoids ought to be kept away from ongoing investigations which have archived a disturbing number of COVID-19 patients with mucormycosis contamination. A large portion of these patients had diabetes which was controlled with the use of steroids.
Conclusion: Thus, the current article underlines mucormycosis and its connected conditions, its component in typical and COVID-19 influenced people, affecting variables and difficulties to defeat this disease. Early distinguishing proof and further examination of its growth will altogether diminish the seriousness of the sickness and death rate in COVID-19- influenced patients.
[http://dx.doi.org/10.3390/jof6020091] [PMID: 32599813]
[http://dx.doi.org/10.1111/myc.13256] [PMID: 33590551]
[http://dx.doi.org/10.1016/j.envres.2021.111643] [PMID: 34237335]
[http://dx.doi.org/10.1093/clinids/14.Supplement_1.S126] [PMID: 1562684]
[http://dx.doi.org/10.1002/rmv.2181] [PMID: 33152146]
[http://dx.doi.org/10.5946/ce.2020.180] [PMID: 33207116]
[http://dx.doi.org/10.1111/myc.13334] [PMID: 34096653]
[http://dx.doi.org/10.1093/cid/ciaa1012] [PMID: 32674114]
[http://dx.doi.org/10.1007/s15010-020-01561-x] [PMID: 33331988]
[http://dx.doi.org/10.1126/science.abh1282] [PMID: 33931567]
[http://dx.doi.org/10.1016/S1473-3099(20)30858-6] [PMID: 33338441]
[http://dx.doi.org/10.1016/S1473-3099(20)30942-7] [PMID: 33485468]
[http://dx.doi.org/10.1002/hpm.3245] [PMID: 34014016]
[http://dx.doi.org/10.1288/00005537-198408000-00013 ] [PMID: 6748833]
[http://dx.doi.org/10.1097/01.TP.0000129798.22312.1E ] [PMID: 15385821]
[http://dx.doi.org/10.1001/archinte.1983.00350050193037 ] [PMID: 6591864]
[http://dx.doi.org/10.1111/j.1365-2141.1995.tb08355.x ] [PMID: 7734347]
[http://dx.doi.org/10.1046/j.1525-1470.2003.20508.x ] [PMID: 14521558]
[http://dx.doi.org/10.1097/00007890-199810150-00021 ] [PMID: 9798707]
[http://dx.doi.org/10.1007/s00134-003-2132-1] [PMID: 14991098]
[http://dx.doi.org/10.1128/JCM.41.8.3623-3626.2003 ] [PMID: 12904365]
[http://dx.doi.org/10.1128/JCM.43.10.5395-5396.2005] [PMID: 16208029]
[http://dx.doi.org/10.1080/10428190410001700803] [PMID: 15370266]
[http://dx.doi.org/10.1111/myc.13353] [PMID: 34255907]
[http://dx.doi.org/10.1002/(SICI)1096-9896(199701)181:1<100::AID-PATH100>3.0.CO;2-O] [PMID: 9072010]
[http://dx.doi.org/10.15585/mmwr.mm695152e1] [PMID: 33382675]
[http://dx.doi.org/10.1093/cid/cir868] [PMID: 22247446]
[http://dx.doi.org/10.1172/JCI82744] [PMID: 27159390]
[http://dx.doi.org/10.1016/S1473-3099(19)30312-3] [PMID: 31699664]
[http://dx.doi.org/10.3324/haematol.2016.152900] [PMID: 28011902]
[http://dx.doi.org/10.1080/13693780412331271072] [PMID: 16010852]