Title:Molecular Mechanisms of miR-214 Involved in Cancer and Drug
Resistance
Volume: 23
Issue: 7
Author(s): Elham Karimi, Aghdas Dehghani, Hanieh Azari, Mahboobeh Zarei, Mohammad Shekari and Pegah Mousavi*
Affiliation:
- Department of Medical Genetics, Faculty of Medicine Hormozgan University of Medical Sciences, Bandar
Abbas, Iran
Keywords:
microRNA, miR-214, target genes, cancer diseases, RNAs, miRNA.
Abstract: As a transcriptional regulation element, the microRNA plays a crucial role in
many aspects of molecular biological processes, like cellular metabolism, cell division,
cell death, cell movement, intracellular signaling, and immunity. Previous studies
suggested that microRNA-214 (miR-214) is probably a valuable cancer marker. In this
study, a brief updated overview of the vital dual role of miR-214 in cancer as a tumor
suppressor or oncogene was provided. We also examined target genes and signaling
pathways related to the dysregulation of miR-214 reported in previous experimental
research on various human diseases. To highlight the critical function of miR-214 in the
prognostic, diagnostic, and pathogenesis of cancer diseases, we focused on the
probable clinical biomarker and drug resistance function of miR-214. The current
research provides a comprehensive perspective of the regulatory mechanisms governed
by miR-214 in human disease pathogenesis and a list of probable candidates for future
study.