Title:A Detailed Review of Various Herbal Treatment Options for Potentially
Curing or Ameliorating Pain in Diabetic Neuropathy
Volume: 9
Issue: 2
Author(s): Pranay Wal*, Priya Singh and Aparna Sinha
Affiliation:
- Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India
Keywords:
Diabetes mellitus, diabetic neuropathy, Momocardia charantia, Curcuma longa, Emblica officinalis, ameliorating pain.
Abstract: Diabetes mellitus (DM) is a group of metabolic disorders associated with hyperglycemia
due to deficient insulin secretion, insulin action, or both. In 2008, out of 36 million deaths due to
non-communicable diseases, 1.3 million deaths alone were causative of DM, suggesting it to be a
significant public health problem, reaching epidemic proportions globally. Diabetic Neuropathy is a
common complication of DM. The pathophysiology of DN involves the interplay of metabolic and
vascular factors, with the principal factor being hyperglycemia. Since DN is a prevalent, disabling
condition associated with nerve injury, efficient treatments include glycaemic control and pain management.
The ancient scriptures like Charak Samhita and modern pharmacology have corroborated
the vast medicinal potential of herbal plants for achieving a more holistic treatment for several ailments.
One of the primary objectives of the current review was to provide collective data on the
available pharmacological evidence of selective herbal plants for future clinical translation. Also,
the herbal extracts used in the studies need to be standardised according to standard protocols. This
is important for understanding the complex effect of specific phytoconstituents at the biomolecular
level and determining the clinical dose to make results more repeatable.