Title:Natural Compounds as Potential Anti-COVID Agents
Volume: 21
Issue: 1
Author(s): Nidhi Rani*, Randhir Singh, Praveen Kumar, Prerna Sharma and Vikas Sharma
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India
Keywords:
Coronavirus, COVID19, natural plants, spike glycoprotein, WHO, MERS.
Abstract:
Background: Since December 2019, COVID-19 has become a new health crisis in
the world and has been declared a public health emergency of international concern by WHO. In
search of anti-COVID treatment regimen, we applied molecular docking approach in order to
identify the natural compounds that may have potential for anti-COVID treatment with specific
target and selective inhibitory mechanism. Our goal is to identify the potential anti-COVID compounds
based on virtual screening of the protein of spike glycoprotein as virtual inhibition target.
Methods: Molecular docking was carried out by using Molergo Virtual Docker. 35 compounds
from different plant sources were selected and docked in the enzyme pocket.
Results: The docking result revealed that some of the compounds exhibited good potency against
the virus and can be used further for developing new drug regimen.
Conclusion: The compounds of natural origin could be a good target and can be used as lead
compounds for the treatment of this dreadful disease.