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Anti-Infective Agents


ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Research Article

Natural Compounds as Potential Anti-COVID Agents

Author(s): Nidhi Rani*, Randhir Singh, Praveen Kumar, Prerna Sharma and Vikas Sharma

Volume 21, Issue 1, 2023

Published on: 09 September, 2022

Article ID: e040422203043 Pages: 11

DOI: 10.2174/2211352520666220404093338

Price: $65


Background: Since December 2019, COVID-19 has become a new health crisis in the world and has been declared a public health emergency of international concern by WHO. In search of anti-COVID treatment regimen, we applied molecular docking approach in order to identify the natural compounds that may have potential for anti-COVID treatment with specific target and selective inhibitory mechanism. Our goal is to identify the potential anti-COVID compounds based on virtual screening of the protein of spike glycoprotein as virtual inhibition target.

Methods: Molecular docking was carried out by using Molergo Virtual Docker. 35 compounds from different plant sources were selected and docked in the enzyme pocket.

Results: The docking result revealed that some of the compounds exhibited good potency against the virus and can be used further for developing new drug regimen.

Conclusion: The compounds of natural origin could be a good target and can be used as lead compounds for the treatment of this dreadful disease.

Keywords: Coronavirus, COVID19, natural plants, spike glycoprotein, WHO, MERS.

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