Title:Mechanism of Mesenchymal Stem Cells as a Multitarget Disease-
Modifying Therapy for Parkinson's Disease
Volume: 21
Issue: 4
Author(s): Aziz Unnisa, Kamal Dua and Mohammad Amjad Kamal*
Affiliation:
- Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China
- King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Bangladesh
- Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770; Novel Global Community Educational Foundation, Australia
Keywords:
Parkinson’s disease, dopaminergic neurons, stem cell, therapy, mesenchymal stem cells.
Abstract: Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders, affecting
the basal nuclei, causing impairment of motor and cognitive functions. Loss of dopaminergic
(DAergic) neurons or their degeneration and the aggregation of Lewy bodies is the hallmark of this
disease. The medications used to treat PD relieve the symptoms and maintain quality of life, but currently,
there is no cure. There is a need for the development of therapies that can cease or perhaps
reverse neurodegeneration effectively. With the rapid advancements in cell replacement therapy
techniques, medical professionals are trying to find a cure by which restoration of dopamine neurotransmitters
can occur. Researchers have started focusing on cell-based therapies using mesenchymal
stem cells (MSCs) due to their abundance in the body, the ability of proliferation, and immunomodulation.
Here we review the MSC-based treatment in Parkinson's disease and the various
mechanisms it repairs DAergic neurons in parkinsonian patients.