Title:Importance of Indazole against Neurological Disorders
Volume: 22
Issue: 14
Author(s): Dilipkumar Pal*Pooja Sahu
Affiliation:
- Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, C.G., 495009, India
Keywords:
Indazole, Alzheimer disease, Parkinson's disease, MAO, GSK-3, LRRK-2, Neurological disorders.
Abstract: Indazole is a nitrogen-containing bicyclic compound, having three tautomeric forms: 1Hindazole,
2H-indazole, and 3H-indazole. Mostly, they are considered as 1H-indazole tautomeric
forms, although they have the potential to tautomerism to 2H- and 3H-indazole forms. Indazoles are
involved in a wide variety of biological and enzymatic processes. Therefore, they exhibit a series of
pharmacological activities. Indazoles show potent activities against neurological disorders such as
Parkinson's disease (PD), Alzheimer's disease (AD), mood disorders, etc., by inhibiting different
signaling pathways and the generation of neurotransmitters and activation of enzyme activity. They
effectively prevent neurological diseases by different mechanisms, such as by inhibiting the monoamine
oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich
repeat kinase enzyme 2 (LRRK2). In this article, we have discussed multiple causative strategies
of indazole to treat neurological diseases. This has aroused special attention in the discovery of
the novel indazoles and their biological activities.