Title:Targeting Ferroptosis Pathways: A Novel Strategy for Cancer Therapy
Volume: 22
Issue: 3
Author(s): Devangkumar Maru, Akhil Hothi, Chintan Bagariya and Anmol Kumar*
Affiliation:
- Department of Biotechnology, Atmiya University, Rajkot-360005, India
Keywords:
Ferroptosis, cancer, redox imbalance, regulated cell death, hallmarks, inducer.
Abstract: Ferroptosis is an iron-dependent nonapoptotic kind of regulated cell death resulting from
the destruction of redox balance in the cytosol. Unlike apoptosis, ferroptosis is caused by an increase
in intracellular iron and lipid peroxides that causes significant damage to the membrane lipid bilayer
and mitochondria leading to cell death. Increased iron level in the cell promotes ROS production.
Ferroptosis inducer molecules increase ROS production and inhibit the antioxidant defence mechanism
to facilitate ferroptosis in cancer cells. Inhibition of GPX4, redox-active iron availability, and
lipid peroxidation are major contributors to ferroptosis. Ferroptosis is involved in many diseases like
heart disease, neurodegenerative disease, and cancer. Ferroptosis induction recently emerged as an
attractive strategy for cancer therapy. In this review, we discuss the regulatory mechanism of ferroptosis,
its different hallmarks, including genetic and metabolic regulators and inducers that promote
ferroptosis in the cancer cells. Finally, the latest progress and development in ferroptosis research in
different cancers focusing on proposing a novel strategy in cancer therapy are discussed.
