Title:Drug Delivery Systems and Strategies to Overcome the Barriers of Brain
Volume: 28
Issue: 8
Author(s): Yogesh Garg, Deepak N. Kapoor, Abhishek K. Sharma and Amit Bhatia*
Affiliation:
- Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, Pin. 151001, India
Keywords:
Nanomedicine, novel drug delivery, blood-brain barrier, neurological disorders, nose to brain, non-invasive.
Abstract: The transport of drugs to the central nervous system is the most challenging task for conventional
drug delivery systems. The reduced permeability of drugs through the blood-brain barrier is a major hurdle in
delivering drugs to the brain. Hence, various strategies for improving drug delivery through the blood-brain barrier
are being explored. Novel drug delivery systems (NDDS) offer several advantages, including high chemical
and biological stability, suitability for both hydrophobic and hydrophilic drugs, and can be administered
through different routes. Furthermore, the conjugation of suitable ligands with these carriers tends to potentiate
targeting to the endothelium of the brain and could facilitate the internalization of drugs through endocytosis.
Further, the intranasal route has also shown potential, as a promising alternate route, for the delivery of drugs to
the brain. This can deliver the drugs directly to the brain through the olfactory pathway. In recent years, several
advancements have been made to target and overcome the barriers of the brain. This article deals with a detailed
overview of the diverse strategies and delivery systems to overcome the barriers of the brain for effective
delivery of drugs.