Title:Nanoparticles Mediated Target-specific Drug Delivery in Prostate
Cancer: An In-depth Review
Volume: 29
Issue: 24
Author(s): Tarun Kumar Upadhyay*, Mohammed Irfan Ali, Fahad Khan, Harsh Goel, Manas Mathur, Keshav Goyal, Sarmad Moin, Pratibha Pandey, Pranay Tanwar, Amit Baran Sharangi, Saloni Dinesh Chandra Gautam, Jhanvi Kiran Kapdi, Kruti Indravadan Patel, Meghna Vipulbhai Patel, Amisha M. Parmar and Mohammad Amjad Kamal
Affiliation:
- Department of Biotechnology, Animal Cell Culture and Immunobiochemistry Lab, Parul Institute of Applied Sciences
and Centre of Research for Development, Parul University, Vadodara, Gujarat, 391760, India
Keywords:
Cancer cell, prostate cancer, cytotoxicity, nanoparticles, targeted delivery, drug delivery.
Abstract: Nanotechnology has been extensively exploited for its enormous therapeutic
and diagnostic potential in the management of multiple disorders. It employs nanomaterials
as drug carriers with enhanced efficacy and limited side effects on normal tissues. A
lot of nanomaterials have been studied and produced, imminently reforming the treatment
and diagnostics of numerous malignancies, including cancer. The purpose of the
present study is to explore the role of nanotechnology-based devices/therapies that have a
vital function in the therapeutics and diagnostics of cancer with potential impact at three
levels: early detection, tumor imaging, and drug delivery methods. Concentrating on cancer,
promising nanotechnology-based approaches have been planned to satisfy the need
for targeted specificity of traditional agents of chemotherapeutics, in addition to early
recognition of malignant and precancerous lesions. Prostate cancer is the fifth most wellknown
cancer worldwide and the second most usually detected cancer in men. Therefore,
there is a crucial need to improve therapeutic prospects for the diagnosis and treatment of
prostate cancer via the exploitation of the potential of nanomaterials for cell-targeted specificity
and improved primary diagnosis of precancerous tumors. The present review,
therefore, focuses on summarizing all prospective applications of nanotechnology in the
prognosis and diagnosis of prostate cancer, which would further help researchers to elucidate
a more potent therapeutic approach for the better management of prostate cancer in
the days ahead.
