Title:β-Dihydroagarofuran-type Sesquiterpenoids from the Stems of Celastrus
orbiculatus with their Cytotoxic Activities
Volume: 19
Issue: 9
Author(s): Yong Hua Lin*, Bao Yan Zhang, Zhi Chao Chen and Jian Feng Wei
Affiliation:
- Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Fujian Medical University,
Quanzhou 362000, China
- The Second Clinical College, Fujian Medical University, Quanzhou 362000, China
Keywords:
Celastrus orbiculatus, celastraceae, Chinese traditional medicine, sesquiterpenoids, cytotoxic activity, structureactivity relationships.
Abstract: A new β-dihydroagarofuran-type sesquiterpenoid named 1α,2α,5α,11-tetraacetoxy-8α-
(trans-p-coumaroyl)-β-dihydroagarofuran (1), together with five known compounds (2-6), was
isolated from the CHCl3-soluble extract of the stems of Celastrus orbiculatus. The structure of the
new compound was elucidated with spectroscopic physicochemical analyses. All isolates were
evaluated for in vitro cytotoxic activity against four human cancer lines, including HepG2, MCF-7,
A549, and HCT-116 cells. Among them, compounds 1 and 6 showed potent cytotoxic activities
against HepG2 cells with IC50 values of 8.78 ± 2.31 and 10.28 ± 1.15 μM, respectively. In addition,
compound 6 exhibited significant cytotoxic activity against HCT-116 cells with an IC50 value of
6.37 ± 2.52 μM.