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Current Topics in Medicinal Chemistry

Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

The Role of Aromatase Enzyme in Hormone Related Diseases and Plant- Based Aromatase Inhibitors as Therapeutic Regimens

Author(s): Kevser Taban Akçaorcid of author, Murside Ayşe Demirelorcid of author and Ipek Süntar*

Volume 22, Issue 3, 2022

Published on: 11 January, 2022

Page: [229 - 246] Pages: 18

DOI: 10.2174/1568026621666211129141631

Price: $65

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Abstract

Medicinal plants have a long history of use as food and remedy in traditional and modern societies. They have been used as herbal drugs and sources of novel bioactive compounds. They provide a wide array of chemical compounds, many of which can not be synthesized via current synthesis methods. Natural products may provide aromatase inhibitory activity through various pathways and may act clinically effective for treating pathologies associated with excessive aromatase secretion, including breast, ovarian, and endometrial cancers, endometriosis, uterine fibroid, benign prostatic hyperplasia (BPH), prostate cancer, infertility, and gynecomastia. Recent studies have shown that natural products with aromatase inhibitory activity can also be good options against secondary recurrence of breast cancer by exhibiting chemopreventive effects. Therefore, screening for new plant-based aromatase inhibitors may provide novel leads for drug discovery and development, particularly with increased clinical efficacy and decreased side effects.

Keywords: Aromatase, Natural products, Medicinal plants, Secondary metabolites, Estrogen, Testosterone.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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