Update on the Biological Relevance of Lysine Acetylation as a Novel Drug Target in Trypanosomatids

Title:Update on the Biological Relevance of Lysine Acetylation as a Novel Drug Target in Trypanosomatids

Volume: 29 Issue: 20

Author(s): Gonzalo Martinez Peralta, Esteban Serra*Victoria Lucia Alonso*

Affiliation:

• Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina
• Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina

• Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina
• Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina

Keywords: Acetylation, acetyltransferases, deacetylases, acetylome, trypanosomatids, cytoskeleton.

Abstract: The number of acetylated proteins identified from bacteria to mammals has grown exponentially in the last ten years, and it is now accepted that acetylation is a key component in most eukaryotic signaling pathways and is as important as phosphorylation. The enzymes involved in this process are well described in mammals; acetyltransferases and deacetylases are found inside and outside the nuclear compartment and have different regulatory functions. In trypanosomatids, several of these enzymes have been described and are postulated to be novel antiparasitic targets for the rational design of drugs. In this review article, we present an update of the most important known acetylated proteins in trypanosomatids, analyzing the acetylomes available. Also, we summarize the information available regarding acetyltransferases and deacetylases in trypanosomes and their potential use as chemotherapeutic targets.

Cite this article as:

Peralta Martinez Gonzalo , Serra Esteban*, Alonso Lucia Victoria*, Update on the Biological Relevance of Lysine Acetylation as a Novel Drug Target in Trypanosomatids, Current Medicinal Chemistry 2022; 29 (20) . https://dx.doi.org/10.2174/0929867328666211126145721