Title:Role of Vitamins in Neurodegenerative Diseases: A Review
Volume: 21
Issue: 9
Author(s): Ravi Ranjan Kumar, Lovekesh Singh, Amandeep Thakur, Shamsher Singh and Bhupinder Kumar*
Affiliation:
- Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, MOGA-142001, Punjab, India
Keywords:
Vitamin, Alzheimer’s disease, parkinson’s disease, multiple sclerosis, Huntington disease, glucose cycle.
Abstract:
Background: Vitamins are the micronutrients required for boosting the immune system
and managing any future infection. Vitamins are involved in neurogenesis, a defense mechanism
working in neurons, metabolic reactions, neuronal survival, and neuronal transmission. Their deficiency
leads to abnormal functions in the brain like oxidative stress, mitochondrial dysfunction, accumulation
of proteins (synuclein, Aβ plaques), neurodegeneration, and excitotoxicity.
Methods: In this review, we have compiled various reports collected from PubMed, Scholar Google,
Research gate, and Science direct. The findings were evaluated, compiled, and represented in
this manuscript.
Conclusion: The deficiency of vitamins in the body causes various neurological disorders like
Alzheimer’s disease, Parkinson’s disease, Huntington's disease, and depression. We have discussed
the role of vitamins in neurological disorders and the normal human body. Depression is linked to
a deficiency of vitamin-C and vitamin B. In the case of Alzheimer’s disease, there is a lack of vitamin-
B1, B12, and vitamin-A, which results in Aβ-plaques. Similarly, in Parkinson’s disease, vitamin-
D deficiency leads to a decrease in the level of dopamine, and imbalance in vitamin D leads to
accumulation of synuclein. In MS, vitamin-C and vitamin-D deficiency causes demyelination of
neurons. In Huntington's disease, vitamin- C deficiency decreases the antioxidant level, enhances
oxidative stress, and disrupts the glucose cycle. vitamin B5 deficiency in Huntington's disease disrupts
the synthesis of acetylcholine and hormones in the brain.
