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Current Neuropharmacology

Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Effects of Histone Modification in Major Depressive Disorder

Author(s): Man-Si Wu, Xiao-Juan Li, Chen-Yue Liu, Qiuyue Xu, Jun-Qing Huang, Simeng Gu and Jia-Xu Chen*

Volume 20, Issue 7, 2022

Published on: 28 March, 2022

Page: [1261 - 1277] Pages: 17

DOI: 10.2174/1570159X19666210922150043

Price: $65

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Abstract

Major depressive disorder (MDD) is a disease associated with many factors; specifically, environmental, genetic, psychological, and biological factors play critical roles. Recent studies have demonstrated that histone modification may occur in the human brain in response to severely stressful events, resulting in transcriptional changes and the development of MDD. In this review, we discuss five different histone modifications, histone methylation, histone acetylation, histone phosphorylation, histone crotonylation and histone β-hydroxybutyrylation, and their relationships with MDD. The utility of histone deacetylase (HDAC) inhibitors (HDACis) for MDD treatment is also discussed. As a large number of MDD patients in China have been treated with traditional Chineses medicine (TCM), we also discuss some TCM therapies, such as Xiaoyaosan (XYS), and their effects on histone modification. In summary, targeting histone modification may be a new strategy for elucidating the mechanism of MDD and a new direction for MDD treatment.

Keywords: Major depressive disorder, histone methylation, histone acetylation, histone phosphorylation, histone crotonylation, histone β-hydroxybutyrylation, HDAC inhibitor.

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Graphical Abstract

Graphical abstract illustrating key findings of the study

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