Title:An Overview on the Role of miR-451 in Lung Cancer: Diagnosis, Therapy,
and Prognosis
Volume: 10
Issue: 3
Author(s): Saiedeh Razi Soofiyani, Kamram Hosseini, Alireza Soleimanian, Liela Abkhooei, Akbar Mohammad Hoseini, Vahideh Tarhriz*Tohid Ghasemnejad*
Affiliation:
- Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran
- Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
miR-451, lung cancer, biomarker, cancer therapy, diagnosis, prognosis.
Abstract: MicroRNAs (miRNAs) are highly conserved non-coding RNAs involved in many physiological
processes such as cell proliferation, inhibition, development of apoptosis, differentiation,
suppression of tumorigenicity, and regulation of cell growth. The description of the alterations of
miRNA expression patterns in cancers will be helpful in recognizing biomarkers for early detection
and possible therapeutic intervention in the treatment of cancers. Recent studies have shown that
miR-451 is broadly dysregulated in lung cancer and is a crucial agent in lung tumor progression.
This review summarizes recent advances in the potential role of miR-451 in lung cancer diagnosis,
prognosis, and treatment and provides an insight into the potential use of miR-451 for the development
of advanced therapeutic methods in lung cancer.
